谷氨酰胺联合大黄治疗重度烧伤的临床效果观察

Curative Effect of Glutamine Combined with Dahuang （ Radix et Rhizoma Rhei） in Treatment of Severe Burns

目的：观察并探讨谷氨酰胺联合大黄治疗重度烧伤的临床效果及其安全性.方法：将2013年12月～2016年12月本院收治的重度烧伤患者62例随机分为观察组和对照组,每组各31例.观察组患者采用烧伤常规治疗＋谷氨酰胺＋大黄治疗,对照组患者采用烧伤常规治疗.比较2组患者治疗前后血浆白蛋白（ALB）、前白蛋白（P-ALB）、转铁蛋白（TF）、内毒素、白介素-17（IL-17）、IL-10及干扰素-γ（IFN-γ）水平以及创面愈合时间、并发症情况.结果：治疗7天后观察组患者血浆ALB、P-ALB、TF显著高于对照组,差别具有统计学意义（P〈0.05）,治疗后观察组患者内毒素、IL-17及IFN-γ水平低于对照组,IL-10水平高于对照组,差别具有统计学意义（P〈0.05）.观察组患者创面愈合时间均优于对照组（P〈0.05）.结论：谷氨酰胺联合大黄治疗能够显著改善重度烧伤患者的营养状况,加快创面愈合,抑制炎症反应发生.

Objective： To assess the curative effect and securityof glutamine combined with Dahuang （Radix et Rhizoma Rhei ） in treatment of severe.bums. Methods： Sixty -two severe bums patients who were treated from December 2013 to December 2016 at Baogang hospital were randomly divided into either an observation group （n = 31） or a control group （n = 31）. The control group was given onventional treatment, and the observation group was given glutamine combined with Dahuang （Radix et Rhizoma Rhei）. Curative effects, setum albumin（ALB）, prealbumin （P- ALB）,tranderrin（TF） ,endotoxin , interleukin 17 （IL- 17） ,IL- 10 and interferon-γ （ IFN -γ）were compared for the two groups. Results：： On the seventh day after treatment, ALB、P - ALB,TF were significantly higher in the observation group compared with the control group （P 〈 0. 05 ）, endotoxin, IL- 17, IFN -γ were significantly lower in the observa- tion group compared with the control group （ P 〈 0.05 ）. IL - 10 was higher in the observation group than in the control group （ P 〈 0. 05 ）. On the twenty - one day after treatment, Wound healing of observation group were better than control group. （ P 〈 0. 05 ）. Conclusion： Glutamlne combined with Dabuang （Radix et Rhizoma Rhei） is able to significantly improve nutritional status , healing and inhibiting inflammatory response in patients with severe burns.