物质依赖的代谢组学研究进展

Development of metabonomics of drug dependence

物质依赖给全球医疗及安全带来沉重负担，目前其机制尚不明确。且由于涉及司法问题，患者对病史多有隐瞒，诊断上存在困难。代谢组学作为新兴的系统生物学技术，能提供理解疾病的新视角。本文综述了目前使用最为广泛的几种成瘾物质的代谢组学的研究进展，认为代谢组学技术有望为物质依赖的临床诊断及治疗提供客观生物标记物。外周代谢组学与中枢神经系统的关系将成为今后的研究重点。多种组学平台的联合应用、大数据以及荟萃分析将提供更多的信息。最终对识别有物质依赖易感倾向的个体，并为他们的预防及治疗提供突破性的进展。

Drug dependence brings heavy burden to globe medicine and security,however,the mechanism is unclear. And because of the legal question, patients tend to hide their history of drug use, which make the diagnosis difficuh. Metabonomics is an emerging system biological technology which can offer a new view about the diseases. This paper reviewed the metabonomics research progress of the main dependence drugs, and proved that metabonomics technology may discover biomarkers for diagnosis and treatment of drug dependenee. The relationship between peripheral metabonomics and center nerve system may become an important research field. More information may come from the united apply of genomics, proteomies and metabo- nomics. Finally,there will be a breakthrough in identification of individuals with susceptibility to drug dependenee, and supply a preventive or treatment plan.