非酒精性脂肪性肝病无创诊断和评估的临床研究进展

Progress in Non-invasive Diagnosis and Assessment of Non-alcoholic Fatty Liver Disease

非酒精性脂肪性肝病(NAFLD)是指除外长期大量饮酒和其他损伤肝脏因素所引起的以肝脏脂肪沉积为主要表现的临床综合征,其发病机制与环境、遗传、免疫等多种因素相关。早期诊断有助于鉴别单纯性非酒精性脂肪肝(NAFL)和非酒精性脂肪性肝炎(NASH),同时可对NAFLD病变程度进行分级并延缓其进一步发展。本文就NAFLD无创诊断和评估的临床研究进展作一综述。

Non-alcoholic fatty liver disease（ NAFLD） is a clinical syndrome characterized by hepatic fat deposition,and not caused by chronic heavy drinking and other liver damage factors. The pathogenesis of NAFLD is associated with environmental,genetic,immune and other various factors. Early diagnosis is helpful not only for distinguishing between simple non-alcoholic fatty liver（ NAFL） and non-alcoholic steatohepatitis（ NASH）,but also for grading the extent of NAFLD lesion and delaying its further development. This article reviewed the clinical research progress of non-invasive diagnosis and evaluation of NAFLD.