胃肠道神经内分泌肿瘤的药物治疗进展

Progress of Drug Treatment for Gastrointestinal Neuroendocrine Neoplasm

神经内分泌肿瘤(NEN)是一类起源于神经内分泌系统的异质性肿瘤,其中以胃肠道神经内分泌肿瘤(GI-NEN)最为常见。GI-NEN发病率逐年增高,但临床疗效不理想。近年GI-NEN的药物治疗研究已取得一系列进展,包括生长抑素类似物、干扰素、mTOR抑制剂、血管内皮生长因子抑制剂、化疗药物等。此外,肽受体介导的放射性核素为转移性GI-NEN治疗提供了更多选择。本文就近年GI-NEN的药物治疗进展作一综述。

Neuroendocrine neoplasm（ NEN） is a group of heterogeneous tumor originated from the neuroendocrine system,and gastrointestinal neuroendocrine neoplasm（ GI-NEN） is the mostly frequently seen. The incidence of GI-NEN is increasing year by year,but the efficacy of clinical treatment is unsatisfactory. In recent years,new progress has been achieved in medical therapy of GI-NEN,including somatostatin analogues,interferon,m TOR inhibitor,vascular endothelial growth factor inhibitor and chemotherapeutic drugs. Peptide receptor radionuclide therapy also provides an additional option for treatment of metastatic GI-NEN. This article reviewed the recent progress of drug treatment for GI-NEN.