血必净注射液联合持续血液净化治疗严重脓毒症患者的疗效观察

Observation on effect of Xuebijing Injection combined with continuous blood purification in treatment of patients with severe sepsis

目的分析血必净注射液联合持续血液净化治疗严重脓毒症患者临床疗效。方法选取该院2013年1月至2016年8月收治的严重脓毒症患者120例,分为对照组与研究组,其中对照组在常规治疗基础上给予血液净化治疗,研究组在对照组基础上联合血必净进行治疗,治疗后比较两组临床疗效。结果两组患者治疗后凝血功能、肾功能均明显改善,研究组明显优于对照组,差异有统计学意义(P<0.05);治疗后研究组多器官功能障碍综合征、脓毒症休克发生率及病死率明显低于对照组,差异有统计学意义(P<0.05)。结论血必净注射液联合持续血液净化治疗严重脓毒症临床效果优异,改善凝血功能及肾脏功能,降低病死率,值得临床广泛推广应用。

Objective To analyze the clinical curative effect of Xuebijing Injection combined with continuous blood purification in treating severe sepsis.Methods One hundred and twenty cases of severe sepsis in the hospital from January 2013 to August 2016 were selected and divided into the control group and research group.The control group was given the blood purification treatment on the basis of conventional treatment,while the research group was combined with Xuebijing Injection for conducting treatment on the basis of the control group.The clinical effects after treatment were compared between the two groups.Results The coagulation function and renal function after treatment in the two groups were significantly improved,but the study group was significantly better than the control group,the difference was statistically significant（P〈0.05）;the incidence rate of multiple organ dysfunction syndrome,septic shock and mortality rate after treatment in the study group were significantly lower than those in the control group,the difference was statistically significant（P〈0.05）.Conclusion Xuebijing Injection combined with continuous blood purification in treating severe sepsis has excellent clinical effect,improves the coagulation function and kidney function,reduces the mortality rate,and is worthy of extensive promotion and application.