谷氨酰胺应用于ICU重症颅脑损伤患者肠外营养支持的效果

Effect of Glutamine in Parenteral Nutrition Support for ICU Patients with Severe Craniocerebral Injury

目的探讨添加谷氨酰胺在ICU重症颅脑损伤患者肠外营养支持中的效果。方法以我院2014年1月至2017年1月收治的40例ICU重症颅脑损伤患者为研究对象,随机分为两组各20例。在常规治疗和护理的基础上,对照组患者予以单纯肠外营养支持,观察组患者在肠外营养液中添加谷氨酰胺注射液。持续治疗2周后,评估比较两组的临床效果。结果两组患者治疗前的营养不良-炎症综合征(MIS)评分比较,差异无统计学意义(P>0.05);治疗后,观察组患者MIS评分为(16.5±1.7)分,显著低于对照组的(19.4±1.8)分(P<0.05)。观察组患者的总并发症发生率为15.0%,显著低于对照组的45.0%(P<0.05)。结论在常规肠外营养支持中添加谷氨酰胺,可以有效地改善ICU重症颅脑损伤患者的营养状态,降低患者的并发症发生风险。

Objective To explore the effect of addition of glutamine in parenteral nutrition support for ICU patients with severe craniocerebral injury. Methods 40 cases of ICU patients with severe craniocerebral injury admitted to our hospital from January 2014 to January 2017 were selected as research objects and randomly divided into two groups equally. On the basis of routine treatment and nursing, the control group received parenteral nutrition support, while the observation group received addition of glutamine injection in parenteral nutrition support. After 2 weeks＇ continuous treatment, the clinical effects of two groups were evaluated and compared. Results Before treatment, no statistical difference was found between two groups in the malnutrition-inflammation syndrome （MIS） score （P 〉0.05）; After treatment, the MIS score of observation group was （16.5±1.7） points, significantly lower than （19.4 ± 1.8） points of control group （P〈0.05）. The total incidence of complications of observation group was 15.0%, significantly lower than 45.0% of control group （P 〈0.05）. Conclusions The addition of glutamine in parenteral nutrition support for ICU patients with severe craniocerebral injury can effectively improve patients＇ condition of nutrition, and reduce the risk of complications.