奥司他韦治疗小儿流行性感冒的疗效及对血清细胞因子的影响

Efficacy of Oseltamivir in the Treatment of Children with Influenza and Its Effect on Serum Cytokines

目的探讨奥司他韦治疗小儿流行性感冒的疗效及对血清细胞因子的影响。方法选取68例流行性感冒患儿,随机分为对照组(对症治疗+利巴韦林治疗,n=34)与观察组(对症治疗+奥司他韦治疗,n=34),观察两组患儿的治疗效果。结果观察组患儿的总有效率显著高于对照组(P<0.05)。观察组患儿的症状改善时间、治疗时间均显著短于对照组(P<0.05)。治疗后,观察组患儿的C-反应蛋白及IL-6、TNF-α水平均显著低于对照组(P<0.05)。观察组的不良反应发生率显著低于对照组(P<0.05)。结论小儿流行性感冒采用奥司他韦治疗具有显著的疗效,可有效缩短病程,减轻炎性反应,不良反应少。

Objective To explore the efficacy of oseltamivir in the treatment of children with influenza and its effect on serum cytokines. Methods 68 cases of children with influenza were selected and randomly divided into the control group （symptomatic treatment ＋ ribavirin treatment） and the observation group （symptomatic treatment ＋ oseltamivir treatment）, with 34 cases in each group. The curative effects of two groups were observed. Results The total effective rate of observation group was significantly higher than that of control group （P〈0.05）. The time for clinical symptom improvement, and treatment duration of observation group were significantly shorter than those of control group （P〈0.05）. After treatment, the levels of C-reactive protein, IL-6 and TNF-a of observation group were significantly lower than those of control group （P〈0.05）. The incidence of adverse reactions of observation group was significantly lower than that of control group （P 〈0.05）. Conclusions Oseltamivir has significant efficacy and few adverse reactions in the treatment of children with influenza, which can shorten the course of disease, and relieve inflammatory reactions.