奥卡西平治疗前庭阵发症的疗效及不良反应

Curative effect and adverse reaction of oxcarbazepine on treating vestibular paroxysmia

目的探讨奥卡西平治疗前庭阵发症的临床疗效,并观察其药物不良反应。方法对26例前庭阵发症患者采用逐步加量法予口服奥卡西平治疗,分别于治疗前、治疗后1、4、8w采用眩晕障碍程度评定量表(DHI)及眩晕评定量表评分系统(DARS)进行评价并对治疗前、后进行对比,同时观察药物不良反应。结果 (1)疗效:治疗后1、4、8w与治疗前相比较DHI量表、DARS评分均有显著改善(P<0.01)。治疗后4、8w较治疗后1w比较疗效有显著改善(P<0.01)。治疗后4、8w相比较疗效无明显差异(P>0.05);(2)不良反应:5例(19.2%)患者出现药物不良反应。结论奥卡西平治疗前庭阵发症疗效显著,不良反应轻微,患者有较好的依从性及耐受性。

Objective To study the curative effect and adverse reaction of oxcarbazepine （ OXC ） on treating vestibular paroxysmia. Method twenty-six patients with diagnosis of vestibular paroxysmia were orally given OXC,and the drug dose was added gradually.We evaluated the curative effect of pre-therapy and post-therapy after the first week, the fourth week and the eighth week by dizziness handicap inventory （ DHI ） and DARS, on the otherhand, the adverse reactionwas studied. Results 1.curative effect：with DHI scales and DARS scales,Comparing with pretherapy, post-therapy after the first week, the fourth week and the eighth week had a significant difference separately （ P〈0.01 ） . Comparing with post-therapy after the first week, the fourth week and the eighth week had a significant difference separately （ P〈0.01 ） .there were no significant difference between the post-therapy after the fourth week and the eighth week （ P〉0.05 ） . 2.Drug adverse reaction：19.2% of patients were found to have adverse reaction. Conclusion Oxcarbazepine is a highly effctive and safe drug which can be used in vestibular paroxysmia.