细胞自噬在肾小管损伤机制中的研究进展

Advances in mechanism of autophagy in renal tubular injury

细胞自噬是由溶酶体介导的清除细胞内受损大分子物质和衰老细胞器的过程,在维持细胞的稳态中有着重要作用。自噬现象普遍存在于所有真核生物细胞中,参与细胞增殖、生长、功能及表型改变等多种重要细胞生理过程的调节。肾小管是多种病因致肾脏损伤的重要靶点,现已在多种肾脏疾病中观察到肾小管上皮细胞自噬的异常。本文就细胞自噬在肾小管损伤中的作用及分子机制的研究进展进行综述。

Autophagy is a lysosome-dependent degradation process that eliminates damaged macromolecular proteins and aging organelles to maintain intracellular homeostasis. Autophagy is observed in almost all eukaryotic cells and plays important roles in many cellular physiological processes, including the cell proliferation and growth, cellular functional alteration and phenotypical tran- sition. Renal tubule is an important target for renal injury under different pathological conditions. Following the discoveries of the molecular basis of autophagy, accumulated lines of evidence have indicated that autophagy dysfunction in tubule is involved in the pathogenesis of many renal diseases. This review will summarize the recent progress in molecule mechanism of autophagy and its roles in renal tubular injury.