健康成年人血浆presepsin正常值参考区间调查

Reference intervals for plasma presepsin in healthy elderly adults

目的建立健康成年人血浆presepsin正常值参考区间。方法按照美国临床和实验室标准化协会(CLSI)C28-A3文件中参考区间研究模式及参考人群筛选标准的要求,测定1 250例20~90岁健康成年人血浆presepsin水平。以非参数百分位数法计算健康成年人血浆presepsin的参考区间,并进行验证。结果不同性别及年龄健康成年人群(20~<30、30~<60、60~<90岁3个年龄组)的血浆presepsin参考区间:男性分别为50~195、47~170、41~142pg/mL;女性分别为43~173、44~162、38~137pg/mL。结论本研究初步建立了健康成年人血浆presepsin的参考区间。

Objective To establish the reference intervals（RIs）for plasma presepsin in healthy population.Methods The document C28-A3 issued by CLSI was a guideline about how to define,establish,and verify reference intervals in the clinical laboratory.Plasma values were determined with CLEIA for 1 250 healthy adults（aged 20-90 years old）,including 624 males and 626 females.The central 95 percentile of RIs were determined using nonparametric statistical methods.Results The presepsin values in elderly population showed a Gaussian distribution and age/sex related changes.The RIs for plasma presepsin in the reference population respective of age（ranged from 20-30,30-60,60-90years）were 50-195,47-170,41-142pg/mL for males and 43-173,44-162,38-137pg/mL for females respectively.Conclusion The RIs for plasma presepsin were established according to the gender and age groups in the healthy adults,and could provide a reference for the clinical and laboratory.