抑郁症患者甲状腺功能变化的研究

The research about changes of thyroid function in patients with depression

目的研究抑郁症患者甲状腺功能的变化情况。方法比较纳入研究的5 316例抑郁症患者(病例组)与5 316例同期健康体检者(对照组)促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)水平的差异;不同性别抑郁症患者TSH、FT3、FT4水平的差异;老年与中青年抑郁症患者甲状腺疾病检出率的差异。结果病例组与对照组TSH、FT3、FT4水平差异有统计学意义(P<0.05);抑郁症患者中男女间TSH、FT3、FT4水平差异有统计学意义(P<0.05);抑郁症患者老年组与中青年组比较,甲状腺功能亢进患者分别占6.50%、6.10%,但差异无统计学意义(P>0.05),亚临床甲状腺功能减退患者分别占24.30%、9.40%,差异具有统计学意义(P<0.05),甲状腺功能减退患者分别占14.30%、2.90%,差异具有统计学意义(P<0.05)。结论甲状腺激素水平降低易引起抑郁症,对易出现甲状腺功能减退的女性及老年人群更应预防抑郁症的发生;甲状腺激素可作为抑郁症的常规筛查指标,但不是特异性指标。

Objective To study thyroid function in patients with depression.Methods The average levels of TSH,FT3,FT4in5 316 patients with depression were compared with 5 316 healthy controls.The average levels of TSH,FT3,FT4 were compared between male and female patients with depression.The differences of thyroid disease detection rate were compared between elder and group younger group.Results The differences of TSH,FT3,FT4 levels between the depression patients and healthy controls have statistically significant（P0.05）.The differences of TSH,FT3,FT4 levels between the male depression patients and the female depression patients have statistically significant（P0.05）.The hyperthyroidism prevalence were as follows：6.50% versus6.10%（P0.05）,compared between older and younger depression patients.The subclinical hypothyroidism prevalence 24.30%versus 9.40%（P0.05）,compared between older and younger depression patients.The hypothyroidism prevalence 14.30% versus2.90%（P0.05）,compared between older and younger depression patients.Conclusion Depression is easily caused by low thyroid hormone levels.Women and elder people with hypothyroidism should more prevent depression.Thyroid hormones can be used as routine screening index of depression,but not specific indicators.