玉米赤霉烯酮对母猪繁殖性能和胎盘免疫相关基因表达量的影响

Effects of Zearalenone on Reproductive Performance and Placenta Immunity Related Gene Expression of Sows

本试验旨在研究饲粮中添加玉米赤霉烯酮(ZEN)对母猪繁殖性能和胎盘免疫相关基因表达量的影响。选择胎次相近、体重200 kg、妊娠第30天的长×大二元杂交母猪40头,随机分为2组,每组20个重复,每个重复1头。对照组饲喂基础饲粮,试验组饲粮在基础饲粮中添加1.5 mg/kg的ZEN。试验期74 d。结果表明,与对照组相比:1)饲粮中添加ZEN显著提高了妊娠期母猪死胎数和弱仔猪数(P<0.05),显著降低了母猪总产仔数(P<0.05);2)饲粮中添加ZEN显著提高了妊娠期母猪血清孕酮含量(P<0.05);3)饲粮中添加ZEN显著提高了妊娠期母猪胎盘中Toll样受体-2(TLR-2)和孕酮受体(PGR)基因表达量(P<0.05)。由此可见,母猪妊娠期饲粮中添加1.5 mg/kg ZEN可显著降低母猪总产仔数,并显著提高死胎数和弱仔猪数。饲粮中低水平的ZEN对母猪繁殖性能仍产生不利影响。

This experiment w as to conducted to study the effects of dietary zearalenone( ZEN) on reproductive performance and placenta immunity related gene expression of sow s. Forty 30 days gestation sow s w ith similar parity and 200 kg body w eight w ere randomly divided into 2 groups w ith 20 replicates per group and 1 pig per replicate. Pigs in the control group w ere fed a basal diet,w hile others in the experimental group w ere fed the basal diet supplemented w ith 1.5 mg/kg ZEN. The experiment lasted for 74 days. The results show ed that compared w ith the control group: 1) dietary supplemented w ith ZEN significantly increased the number of stillborn piglets and number of w eak born piglets of pregnant sow s( P < 0. 05),and significantly decreased the number of total born piglets of sow s( P< 0.05); 2) dietary supplemented w ith ZEN significantly increased the serum progesterone content of pregnant sow s( P < 0. 05); 3) dietary supplemented w ith ZEN significantly increased the expressions of Toll-like receptor-2( TLR-2) and progesterone receptor( PG R) in placenta of pregnant sow s( P<0.05). In conclusion,dietary supplemented with 1.5 mg/kg ZEN can significantly decrease the number of total born piglets,and significantly increase the number of stillborn piglets and number of w eak born piglets of pregnant sow s. Dietary low level of ZEN still has adverse effect on reproductive performance of sow s.[Chinese Journal of Animal Nutrition,2017,29( 10) : 3696-3702]