血红细胞压积、尿素氮在急性胰腺炎早期病情判断中的临床价值

Clinical value of hematocrit and urea nitrogen in the judgment of early stage of acute pancreatitis

目的探讨血红细胞压积(HCT)、尿素氮(BUN)及两者联合检测在急性胰腺炎(AP)早期病情判断中的临床价值。方法本研究共纳入86例急性胰腺炎患者为病例组,40例健康者为对照组。根据急性胰腺炎诊治指南将病例组分为轻症急性胰腺炎(MAP)组50例和重症急性胰腺炎(SAP)组36例。检测各组患者入院24 h内的血清红细胞压积、尿素氮水平。比较各组间血清学指标的差异,通过ROC曲线了解其在重症胰腺炎中的诊断价值。结果 SAP组中HCT和BUN水平高于MAP组,差异有显著性(P<0.05)。早期HCT和BUN诊断SAP的敏感度分别为55.56%和61.11%,特异度分别为86.67%和88.89%,阳性预测值分别为62.50%和68.75%。阴性预测值分别为82.99%和85.11%。结论红细胞压积(HCT)、尿素氮(BUN)可以作为早期评估AP严重程度的敏感指标。

Objective To investigate the clinical value of hematocrit(HCT), urea nitrogen(BUN) and the combined detection of both in the judgment of early stage of acute pancreatitis(AP). Methods A total of 86 patients with acute pancreatitis were enrolled in the study as the case group and another 40 healthy subjects were assigned to the control group. According to the guidelines of diagnosis and treatment of acute pancreatitis, the case group patients were divided into mild acute pancreatitis(MAP) group(50 cases) and severe acute pancreatitis(SAP) group(36 cases). Serum hematocrit and urea nitrogen levels were measured within 24 hours of admission. The differences of serological indicators were compared among the groups. Through the ROC curve, its diagnostic value in severe pancreatitis was investigated. Results The levels of HCT and BUN in SAP group were significantly higher than those in MAP group, and the difference was significant(P<0.05). The sensitivity of early HCT and BUN in the diagnosis of SAP was 55.56% and 61.11% respectively. The specificity was 86.67% and 88.89% respectively. The positive predictive value was 62.50% and 68.75%respectively, and the negative predictive values was 82.99% and 85.11% respectively. Conclusion Hematocrit(HCT)and urea nitrogen(BUN) can be used as a sensitivity index for early assessment of AP severity.