酮替芬治疗感冒后咳嗽的系统评价

Ketotifen in the treatment of post-cold cough :A systematic review

目的评价酮替芬治疗感冒后咳嗽临床疗效与安全性。方法检索主要中英文数据库从建库至2015年12月20日酮替芬治疗感冒后咳嗽随机对照试验研究,筛选合格研究。Cochrane评价员手册、Jadad评分法分别进行偏倚风险评价及质量评价。应用Rev Man5.3软件进行Meta分析。结果符合纳入标准的文献共3篇。Meta分析结果显示,酮替芬治疗感冒后咳嗽治疗组与对照组相比,临床疗效总有效率比值比(odds ratio,OR)为9.44,95%可信区间(confidence interval,CI)(2.81,31.70),差异有统计学意义(P=0.0003);不良反应OR为1.94,95%CI(0.40,9.54),差异无统计学意义(P=0.41)。结论酮替芬治疗感冒后咳嗽有显著临床疗效,但仍需更多高质量、大样本的临床研究来进一步验证。

Objective To evaluate the clinical efficacy of ketotifen in the treatment of post-cold cough. Methods Main database from the inception of each database up to 20 December 2015 were electronically searched. Randomized clinical trials(RCTs) of ketotifen for post-cold cough were included. The Cochrane risk of bias tool was used to assess the risk of bias. Jadad rating scale was used to assess the quality of included studies. The Cochrane Collaboration's RevMan5.3 software was used for meta-analysis. Results Three studies were included and made a meta-analysis. The meta-analysis results showed that the clinical total efficiency rate,whose odds ratio(OR) was 9.44,95% confidence interval(confidence interval,CI)(2.81,31.70),the difference was statistically significant(P=0.0003) in ketotifen treatment group comparing with control group; the adverse reactions rate,whose OR was 1.94,95%CI(0.40,9.54),there was no statistically significant difference(P=0.41) between the two groups. Conclusion Ketotifen in the treatment of post-cold cough has significant clinical curative effect and good safety. High quality and large sample clinical studies are needed for further verification.