血清脂蛋白(a)水平与高血压的相关性

Correlation between hypertension and serum lipoprotein(a) level

目的探讨血清脂蛋白(a)[LP(a)]水平与高血压的相关性。方法对入选的300例患者(高血压患者178例,非高血压患者122例)进行信息采集(性别、年龄、体质量、身高、吸烟史、饮酒史、糖尿病、心脏病、动脉硬化等疾病史)、血压测量、血液生化检验[LP(a)]。结果本组资料总人群LP(a)中位数为97.5 mg/L,高血压组为104.5 mg/L,非高血压组为73.3 mg/L,2组差异有统计学意义(P<0.05)。在高血压组LP(a)>300 mg/L比例较非高血压组高,差异有统计学意义(P<0.05)。对高血压相关影响因素进行Logistic回归分析,经变量筛选后得到的主要影响因素为年龄(OR=1.067,95%CI为1.040~1.095)。结论高血压人群中血清LP(a)水平较非高血压人群高,但LP(a)可能并非是高血压发生发展的主要危险因素。

Objective To investigate the correlation between serum lipoprotein（ a）[LP（ a） ]level and hypertension. Methods The materials of 300 patients（ 178 cases with hypertension,122 cases without hypertension） were collected,including gender,age,weight,height,smoking history,drinking history,history of diseases such as diabetes,heart disease and arteriosclerosis）,and blood pressure and LP（ a） were measured. Results The median level of LP（ a） in the total sample was 97. 5 mg/L,104. 5 mg/L in the cases with hypertension and 73. 3 mg/L in the cases without hypertension. There was significant difference between cases with hypertension and cases without hypertension（ P〈0. 05）. The ratio of LP（ a）〉 300 mg/L in cases with hypertension was significantly higher than that in cases without hypertension（ P〈0. 05）. Logistic regression analysis for hypertension-related influencing factors showed that the main influencing factor was age（ OR =1. 067,95% CI： 1. 040 ～ 1. 095）. Conclusion The serum LP（ a） level in the people with hypertension is higher than that without hypertension,but the LP（ a） may not be a major risk factor for the development of hypertension.