宫颈癌患者促性腺激素释放激素蛋白阳性表达及影响因素分析

Analysis on positive expression of gonadotrophin-releasing hormone protein and the influencing factors

目的探讨宫颈癌患者促性腺激素释放激素(GnRH)阳性蛋白表达及其临床意义。方法选取2014年8月-2016年8月在该院接受治疗的110例宫颈癌患者的临床资料作为宫颈癌组;选取同期110例慢性宫颈炎患者的临床资料作为慢性宫颈炎组。观察两组患者GnRH蛋白阳性表达率,比较不同临床病理特征宫颈癌患者GnRH蛋白阳性表达率的差异,分析影响宫颈癌患者GnRH蛋白阳性表达率的因素。结果宫颈癌组患者宫颈组织中的GnRH蛋白阳性表达率明显高于慢性宫颈炎组(χ~2=130.725,P<0.001);临床分期为Ⅲ期、中低分化、有浸润和转移的宫颈癌患者宫颈组织中GnRH蛋白阳性表达率较高,而不同年龄患者GnRH蛋白阳性表达率比较差异无统计学意义(P>0.05);将单因素分析有意义的因素作为自变量,以GnRH蛋白阳性表达率作为因变量,进行Logistic回归分析。结果显示临床分期和组织学分级是宫颈癌患者GnRH蛋白阳性表达的影响因素(OR=4.895、5.112,P<0.05)。结论宫颈癌患者的GnRH蛋白阳性表达率较高,与患者的临床分期和组织学分级密切相关。

Objective To explore the positive expression of gonadotrophin-releasing hormone （GnRH） protein and the clinical significance. Methods The clinical data of 110 patients with cervical cancer （cervical cancer group） and 110 patients with chronic cervicitis （ chronic eervieitis group） who were treated in the hospital from August 2014 to August 2016 were retrospectively analyzed. The positive expression rates of GnRH protein were observed in the two groups, the differences of the positive expression rates of GnRH protein in cervical cancer patients with different clinicopathological characteristics Were compared, and the factors affecting the positive e：~pression rate of GnRH protein in patients with cervical cancer were analyzed. Results The positive expression rate of GnRH protein in cervical cancer group was statistically significantly higher than that in chronic cervicitis group （χ^2 = 130. 725, P〈0. 001 ） ; the positive expression rates of GnRH protein in cervical cancer patients with stage IH, moderate to low differentiation, invasion, and metastasis were higher, but there was no statistically significant difference in the positive expression rate of GnRH protein among different age groups （ P〉0. 05 ） . Logistic regression analysis was performed taking the factors with significance in univariate analysis as the independent variable and the positive expression rate of GnRH protein as the dependent variable, the results showed that clinical stage and histological grade were the factors affecting the positive expression rate of GnRH protein in cervical cancer patients （ OR = 4. 895, 5.112, P〈0. 05 ） . Conclusion The positive expression rate of GnRH protein in cervical cancer patients is high, and it is closely related to clinical stage and histological grade.