25-羟维生素D水平在儿童过敏性疾病中的表达及其对治疗指导的价值

Expression level of 25-hydroxyvitamin D in children with allergic diseases and its value for guiding treatment

目的分析与探讨25-羟维生素D水平在儿童过敏性疾病中的表达,并研究其对疾病治疗的指导价值及评价。方法将2014年4月-2016年4月经广州医科大学附属第三医院荔湾医院检查临床确诊后进行治疗的93例过敏性疾病患儿选为观察组,随机选取93例健康儿童为对照组,比较两组儿童25-羟维生素D水平。经过系统治疗后,观察并评价过敏性疾病儿童不同病情控制期的25-羟维生素D水平差异。结果观察组患儿25-羟维生素D(25.56±9.33)mmol/L明显低于对照组儿童(45.72±12.28)mmol/L,差异有统计学意义(P<0.05)。经过治疗后,观察组患儿中完全控制组25-羟维生素D水平高于部分控制组及无有效控制组,疾病控制期不同控制水平患儿血清25-羟维生素D水平差异有统计学意义(P<0.05)。结论 25-羟维生素D水平与儿童过敏性疾病的表达相关,有助于疾病的诊断。且随着病情的控制,25-羟维生素D水平明显增高,对疾病治疗具有较优的指导价值,有助于病情及治疗效果的监测。

Objective To analyze and explore the expression of 25-hydroxyvitamin D in children with allergic diseases, research its value for guiding treatment and evaluation. Methods Ninety-three children diagnosed as allergic diseases definitely and treated in the hospital from April 2014 to April 2016 were selected as observation group, and 93 healthy children were randomly selected as control group. The levels of 25-hydroxyvitamin D in the two groups were compared. After systematic treatment, the differences of 25-hydroxyvitamin D levels in allergic diseases children at different disease-controlled stages were observed and evaluated. Results The level of 25-hydroxyvitamin D in observation group was （25.56 ± 9.33 ） retool/L, which was statistically significantly lower than that in control group[ （45.72 ± 12.28 ） mmoL/L ] （P〈0. 05 ） . After treatment, the level of 25-hydroxyvitamin D in complete control group was higher than those in partial control group and ineffective control group, there was statistically significant difference in the level of serum 25-hydroxyvitamin D among the children at different disease-controlled stages （ P〈0. 05 ） . Conclusion The level of 25-hydroxyvitamin D is related to allergic diseases in children, which is contribute to the diagnosis of allergic disease. With the control of the disease, the level of 25-hydroxyvitamin D increases significantly, which has good value for guiding treatment, and it is contribute to monitoring of the disease and therapeutic effect.