温胆片治疗痰浊证动脉粥样硬化斑块的超声形态学评价

Ultrasonic Morphological Evaluation on Wendan Tablets in the Treatment of Atherosclerotic Plaques in Patients with Phlegm Turbidity Syndrome

目的运用高分辨率超声技术检测痰浊证患者动脉粥样硬化斑块形态学特征,探讨温胆片稳定斑块的价值。方法选取30例动脉粥样硬化斑块痰浊证患者,给予口服温胆片治疗(3 g/d),疗程3个月,治疗前、后分别行高分辨率超声测定颈动脉内-中膜厚度(IMT)、斑块厚度、斑块面积,分析斑块回声类型,对比分析治疗前后参数变化。结果治疗后,斑块回声增强,颈动脉IMT减低、斑块厚度降低、面积减小,差异具有统计学意义(P<0.05)。结论温胆片可以稳定痰浊证患者动脉粥样硬化斑块,高分辨率超声可以客观、量化进行评价,为诊断及治疗提供可靠依据。

Objective To investigate the atherosclerotic plaques in patients with morphological characteristics by high-resolution ultrasound, and the effects of Wendan tablet on atherosclerotic plaque. Methods 30 cases of carotid atherosclerosis patients were selected.They were given oral Wendan tablet（ 3g/day） for 12 weeks. Each individual was measured the carotid intima-media thickness（IMT）, Plaque thickness, plaque area. Parameters before and after treatment changes was compared. Results After treatment, plaque echo enhancement, carotid IMT decreased, plaque thickness decreased, and plaque area decreased（P〈0.05）. Conclusion Wendan tablet significantly inhibits the development progression of atherosclerosis. High-resolution ultrasound is a feasible noninvasive imaging to evaluate plaque stability.