利托君用于先兆早产合并前置胎盘对产妇出血及新生儿结局的临床观察

Clinical observation of ritodrine on colporrhagia and neonatal outcomes in patients with threatened premature labor and placenta previa

目的:探讨利托君用于先兆早产合并前置胎盘对产妇出血及新生儿结局的影响。方法:选取68例先兆早产合并前置胎盘患者随机分为对照组(予硫酸镁注射液)和研究组(予盐酸利托君注射液)各34例。比较两组患者的保胎效果、阴道出血量、新生儿结局及不良反应发生情况。结果:研究组患者的保胎成功率和延长孕周时间明显高于对照组(94.12%vs 76.47%)、[(17.68±14.72)d vs(11.19±10.12)d],而阴道出血量低于对照组[(224.73±6.54)ml vs(274.38±7.52)ml](P<0.05);两组患者的新生儿出生体重、窒息率和死亡率、不良反应发生率比较均无统计学意义(P>0.05)。结论:利托君用于先兆早产合并前置胎盘的治疗,可延长孕周时间,提高保胎成功率,改善新生儿结局,安全有效,值得应用于临床。

Objective： To discuss the clinical observation of ritodrine on colporrhagia and neonatal outcomes in patients with threatened premature labor and placenta previa. Methods： Sixty-eight patients with threatened premature labor and placenta previa were randomly selected and divided into a control group （giving magnesium sulfate injection） and a research group （giving ritodrine hydrochloride injection） with 34 patients each. The effect of fetal protection, vaginal bleeding volume, neonatal outcomes and adverse reactions were compared between the two groups. Results： The success rate of the fetal protection was higher （94.12% vs 76.4%） and the time for the delayed pregnancy was longer [07.68±14.72） d vs （11.19±10.12） d] while the vaginal bleeding volume was less [（224.73±6.54） ml vs （274.38±7.52） ml] in the research group than in the control group （P〈0.05）. The comparison of the birth weight, neonatal asphyxia rate and mortality rate of the newborns and the incidence of adverse reactions between the two groups showed no statistical significance （P〉0.05）. Conclusion： Ritodrine for the treatment of patients with threatened premature labor and placenta previa can extend gestational age, increase the success rate of fetal protection and improve the neonatal outcomes, which is safe and effective and worthy of clinical use.