2例抗菌药物引起的药物热分析

Analysis of drug fever caused by two antibacterial agents

目的:临床药师通过参与诊治2例抗菌药物所致药物热患者的临床实践,探讨药物热的判断、干预和转归。方法:2例泌尿外科患者在抗感染治疗过程中出现发热,临床药师查看患者后,分别考虑为两性霉素B脂质体和替考拉宁引起的药物热。结果:医生采纳临床药师意见,2例患者经停用相关药物后体温均降至正常。结论:临床药师可协助临床识别药物热,避免患者药源性损害事件的进一步发展。

Objective： To explore the judgement, intervention and outcome of drug fever caused by two antibacterial agents in clinical practice participated in by clinical pharmacists. Methods： Two cases of drug fever caused by amphotericin B liposome or teicoplanin were found by clinical pharmacists when fever occurred in two patients during their anti-infection treatment. Results： The body temperature of the patients was dropped to normal after physician adopted pharmacist＇s suggestion to discontinue the antibacterial agents they used. Conclusion： Clinical pharmacist can assist clinical physician to identify the drug fever and to avoid the further development of drug-induced damage event.