摘要
目的观察性腺弥漫大B细胞淋巴瘤(DLBCL)的临床病理及免疫表型特点,探讨其病理诊断方法及预后。方法回顾性分析10例性腺DLBCL患者临床病理资料,包括形态学、免疫组织化学,并复习相关文献。结果10例患者中9例为睾丸DLBCL,患者年龄40-85岁,中位年龄67岁;1例为卵巢DLBCL,年龄46岁。光学显微镜下可见肿瘤细胞中等大小或偏大,弥漫一致浸润性分布,睾丸肿瘤组织可见残留的曲细精管。Hans分型以非生发中心B细胞型(non-GCB型)为主(70%,7/10)。随访6-103个月,失访2例,患者1、3、5年生存例数分别为4、2、2例。结论原发性性腺DLBCL少见,多为non-GCB型,预后不佳,可采用手术及化疗等综合治疗,预后需多因素综合评价。
Objective To investigate the clinicopathologic characteristics, immunophenotype, differential diagnosis, and prognostic factors of gonadal diffuse large B-cell lymphoma (DLBCL). Methods The clinicopathologic data of 10 patients with gonadal DLBCL including morphology and immunohistochemistry were analyzed retrospectively, then the literature was reviewed. Results Among 10 patients, 9 cases were testicular DLBCL, and the median age was 67 years old (40-85 years old); 1 case was ovary DLBCL, and the age was 46 years old. Tumor cells were large to medium-sized under the optical microscope, which were characterized as diffuse infiltration around the duct and the remaining convoluted tubule of testis neoplasms. Most DLBCL (70 %, 7/10) immunophenotype analysis showed non-germinal center B-cell (non-GCB) type. Patients were followed up from 6 to 103 months, and 2 patients lost follow-up. The survival number of patients in 1-year, 3-year, and 5-year was 4, 2, 2 respectively. Conclusions Primary gonadal DLBCL is an uncommon extranodal lymphoma, which mainly belongs to non-GCB type with poor prognosis. Comprehensive treatments usually take operation and chemotherapy, and the prognosis should be evaluated by multiple factors.
作者
王志强
周先明
王烈
Wang Zhiqiang Zhou Xianming Wang Lie(Department of Pathology, the Second People' s Hospital of Anhui Province, Hefei 230011, China Department of Urinary Surgery, the People' s Hospital of Chizhou, Chizhou 247000, China Clinical Laboratory, the People' s Hospital of Chizhou, Chizhou 247000, China)
出处
《白血病.淋巴瘤》
CAS
2017年第9期533-535,540,共4页
Journal of Leukemia & Lymphoma
关键词
淋巴瘤
大B-细胞
弥漫性
肿瘤
性腺组织
睾丸
卵巢
临床特点
病理分型
预后
Lymphoma, large B-cell, diffuse
Neoplasms, gonadal tissue
Testis
Ovary
Clinical characteristic
Pathological subtype
Prognosis