放化疗同步和单纯放疗治疗老年晚期非小细胞肺癌的近期疗效及不良反应

Short-term efficacy and adverse reaction of radiotherapy and concurrent chemoradiotherapy in elderly patients with advanced non-small cell lung cancer

目的比较单纯放疗和放化疗同步治疗老年晚期非小细胞肺癌的临床价值。方法老年晚期非小细胞肺癌患者98例按照随机、对照原则分为观察组和对照组各49例。对照组接受单纯放疗治疗，观察组采用同步放化疗方案，观察分析两组患者的临床治疗效果及不良反应发生情况。结果观察组总治疗有效率（65．31％）明显高于对照组（34．69％），差异有统计学意义（P〈0．05）；观察组恶心、呕吐发生率（85．71％）明显高于对照组（42．86％），差异有统计学意义（P〈0．05），但患者均可耐受。结论采用同步放化疗治疗老年晚期非小细胞肺癌，可有效增强近期疗效，且不会引起严重不良反应，有利于患者生活质量的提高和生存期的延长。

Objective To compare the clinical value of radiotherapy and concurrent chemoradiotherapy in elderly patients with advanced non-small cell lung cancer （NSCLC）. Methods Ninety-eight patients with NSCLC were randomly divided into observation group and control group and 49 cases in esch group. The patients in the control group received radiotherapy alone, and the patients in the observation group were treated by concurrent chemoradiotherapy. The clinical efficacy and adverse reaction of the two groups were observed and analyzed. Results The total effective rate of the treatment group （65.31% ） was significantly higher than that of the control group （34. 69% ）, the difference was significant （P 〈 0. 05 ）. The incidence of nausea and vomiting in the observation group （85.71% ） was significantly high- er than that in the control group （42. 86% ）, the difference was significant （ P 〈 0. 05 ）, but patients were tolerable. Conclusions Using concurrent chemoradiotherapy in elderly patients with advanced nonsmall cell lung cancer, can effectively enhance the short-term effect, and will not cause serious adverse reaction, so it is conducive to the improvement of quality of life of patients and the extension of survival.