噪声对细胞体系检测弱激素信号影响的化学动力学模拟

The Simulation of Chemical Dynamics about the Influence of Noise on the Detection of Weak Hormonal Signal in a Cell System

该文通过构建细胞体系的介观随机模型,采用计算机模拟的方法,探讨了共存的内、外噪声对细胞体系检测弱激素信号的影响。结果表明,在外噪声存在时,内噪声强度的增加对弱激素信号的检测起消极作用;在内噪声存在时,有一个最佳的外噪声强度,使得体系对弱激素信号的检测能力最佳;在大多数高等动植物组织的细胞体积范围内,始终有内信号随机共振现象发生,且存在一个最佳的外噪声强度(2.0~3.0),使得细胞体系检测弱激素信号的能力最强。生物体系很可能已经学会自我调节到一个最佳的细胞体积,从而较好地利用外噪声的积极作用。该研究结果很可能对生命体系检测弱信号的机理研究具有一定的参考意义。

By constructing a mesoscopic stochastic model of a cell system, we have investigated the influence of internal and external noise on the detection of weak hormonal signal using computer simulation method. The results showed that the increases of the internal noise intensity played a negative role in the detection of weak hormonal signal with the existence of external noise; and in the presence of internal noise, the ability of the detection of weak signal was the best at optimal external noise intensity. The results showed that there always existed internal signal stochastic resonance in the range of cell volumes of mostly higher flora and fauna, and the cell system had the strongest ability to detect weak signals at an optimal external noise intensity（2.0-3.0）. The biological system is likely to have learned to self-regulate their system volume to an optimal one, thereby make use of the positive effects of external noise. Our findings might have implications for the mechanism of weak signal detecting process in living systems.