摘要
筛选自由基清除剂常用黄嘌呤氧化酶氧化黄嘌呤产生O_2^-·,但此体系中黄嘌呤氧化酶易被药物抑制。
Alkaline Dimethyl Sulfoxide-H_2O-Luminol system was used to investigate superoxide anion-scavenging effects of Ginsenosides (GS) , Gypenosides (GP) , Panax notoginseng saponins (PNS), and Panaxadiol (PA) in vitro. Chemiluminescence produced from the system mentioned above may be inhibited in dosedependent manner by GS, GP, PNS, PA, Caffeic acid and superoxide dismutase. Concentration of fifty percentage of inhibition (IC50) are 38.8, 46.4, 52.1 and 97.8 μg/ml for GS, GP, PNS, and PA, respectively. In conclusion, Ginsenosides-related glycosides may exhibit their pharmacological action through scavenging superoxide anion.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1991年第1期41-43,共3页
Journal of China Pharmaceutical University
关键词
人参皂甙
自由基
超氧阴离子
Chemiluminescence
Alkaline dimethyl sulfoxide
Gypenosides
Panax notoginseng saponins
Ginsenosides
Panaxadiol
