血清TNF-α及IL-6水平与2型糖尿病合并盐敏感性高血压的关系研究

Correlation of the level TNF-α,IL-6 and salt sensitive hypertension patients with type 2 diabetes mellitus

目的探讨TNF-α和IL-6与2型糖尿病合并盐敏感性高血压的关系。方法选择342例2型糖尿病患者,伴有高血压患者286例,其中185例为盐敏感性高血压患者,101例为非盐敏感性高血压患者,选择56例单纯糖尿病患者作为对照组。比较单纯糖尿病组及糖尿病合并高血压组、盐敏感性高血压组与非盐敏感性高血压组患者TNF-α及IL-6水平的变化。结果糖尿病合并高血压组较单纯糖尿病组TNF-α[(97.42±47.15)比(70.73±48.41)ng/m L]及IL-6[(66.57±24.75)比(51.66±23.52)ng/m L]显著增高(P<0.05);盐敏感性高血压组较非盐敏感性高血压组TNF-α[(98.36±46.63)比(76.455±49.47)ng/m L]及IL-6[(65.75±21.46)比(55.52±26.27)ng/m L]亦明显升高(P<0.05)。结论 TNF-α及IL-6在2型糖尿病合并盐敏感性高血压患者发病中具有重要作用。

Objective To explore the association of TNF -α and IL- 2 level with salt sensitive hypertension （SS） in patients with type 2 diabetes mellitus （T2DM）. Methods 342 patients with T2DM were selected, there were 286 patients with hypertension,in- eluded 185 cases with salt sensitive hypertension, 101 cases with non -salt sensitive hypertension. Another 56 patients with pure diabetes as control group. Compared the levels of TNF - α and IL - 2 in patients with T2DM and T2DM with hypertension. And the levels in pa- tiems with salt sensitive hypertension and non - salt sensitive hypertension group. Serum levels of TNF - α and IL - 2 were measured by ILISA methods. Results The levels of TNF - α and IL - 6 were significantly higher in patients with hypertension than those in control group. TNF-α （97.42 ±47.15 ） ,IL- 6 （66.57 ±24.75 ） were higher in patients with hypertension than TNF -α （70.73 ± 48.41 ）, IL - 6 （51.66 ± 23.52） in control group. Further analysis TNF - α （98.36 ± 46.63） and IL - 6 （ 65.75 ±21.46） levels were signifi- cantly higher in salt sensitive hypertension patients than that in non - Salt sensitive hypertension TNF -α （ 76. 455 ± 49.47 ） , IL - 6 （55.52 ± 26.27） （P 〈 0.01 ）. Conclusion TNF - α and IL - 6 may play an important role in the development of salt sensitive hyper- tension in patients with type 2 diabetes.