摘要
调脂药物主要包括,胆固醇生物合成酶抑制剂(他汀类药物)、胆酸螯合剂、贝特类、胆固醇吸收抑制剂、烟酸类以及中药调脂药物等。其中他汀类药物在动脉粥样硬化性心血管疾病(ASCVD)的防治中具有举足轻重的作用,但是他汀降脂治疗仍面临很多问题,不能完全解决血脂代谢异常的问题。近年非他汀调脂药物取得的新进展为强化降脂治疗提供了更多选择。本文重点论述近年来非他汀类调脂药物在ASCVD治疗中取得的进展,强调非他汀调脂药物在ASCVD治疗中的重要性。
Lipid-lowering drugs include 3-hydroxy-3-methylglutaryl coenzyme A( HMG-Co A) reductase inhibitors( statins),bile acid sequestrants( resins),fibric acids,cholesterol absorption inhibitors,niacin and Chinese medicine in treating hyperlipidemia.Although statins plays a decisive role in the prevention and treatment of ASCVD,but it cannot solve all the disorders of lipid metabolism. Recent advances in non-statin drugs provide definitive evidence for abnormal lipid metabolism. This article discusses the non-statin lipid lowering drugs in atherosclerosis cardiovascular disease in recent years and emphasizes the importance of nonstatin lipid lowering drugs on the treatment of ASCVD.
出处
《医学与哲学(B)》
2017年第9期16-18,共3页
Medicine & Philosophy(B)
关键词
降脂药
低密度脂蛋白胆固醇
治疗
动脉粥样硬化性心血管疾病
lipid-lowering drugs
Low-density lipoprotein(LDL)
therapy
atherosclerotic cardiovascular disease(ASCVD)