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非他汀类调脂药物研究进展 被引量:2

Evolving Roles of Non-statin Drugs
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摘要 调脂药物主要包括,胆固醇生物合成酶抑制剂(他汀类药物)、胆酸螯合剂、贝特类、胆固醇吸收抑制剂、烟酸类以及中药调脂药物等。其中他汀类药物在动脉粥样硬化性心血管疾病(ASCVD)的防治中具有举足轻重的作用,但是他汀降脂治疗仍面临很多问题,不能完全解决血脂代谢异常的问题。近年非他汀调脂药物取得的新进展为强化降脂治疗提供了更多选择。本文重点论述近年来非他汀类调脂药物在ASCVD治疗中取得的进展,强调非他汀调脂药物在ASCVD治疗中的重要性。 Lipid-lowering drugs include 3-hydroxy-3-methylglutaryl coenzyme A( HMG-Co A) reductase inhibitors( statins),bile acid sequestrants( resins),fibric acids,cholesterol absorption inhibitors,niacin and Chinese medicine in treating hyperlipidemia.Although statins plays a decisive role in the prevention and treatment of ASCVD,but it cannot solve all the disorders of lipid metabolism. Recent advances in non-statin drugs provide definitive evidence for abnormal lipid metabolism. This article discusses the non-statin lipid lowering drugs in atherosclerosis cardiovascular disease in recent years and emphasizes the importance of nonstatin lipid lowering drugs on the treatment of ASCVD.
出处 《医学与哲学(B)》 2017年第9期16-18,共3页 Medicine & Philosophy(B)
关键词 降脂药 低密度脂蛋白胆固醇 治疗 动脉粥样硬化性心血管疾病 lipid-lowering drugs Low-density lipoprotein(LDL) therapy atherosclerotic cardiovascular disease(ASCVD)
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