针刺治疗慢性偏头痛神经可塑性影响机制

Mechanism of neural plasticity of acupuncture on chronic migraine

慢性偏头痛是致残率高但关注度不足的一种神经功能障碍疾病。大量的临床研究表明中国传统的针刺疗法是一种疗效高、不良反应少的治疗方式。通过对1981年至2017年中国知网及Pub Med数据库中针灸和偏头痛相关的文献进行分析总结,探索针刺对慢性偏头痛神经可塑性影响机制。认为慢性偏头痛的进展涉及神经可塑性在神经结构和功能的改变,并从电生理、分子生化和影像学3个方面论证偏头痛慢性化过程中与神经敏化有关的神经可塑性;针刺亦通过其神经可塑性机制治疗和预防慢性偏头痛,但目前并没有相关的文献总结,阻碍了针刺治疗慢性偏头痛的进一步传播和发展。

Chronic migraine is one of neurological disorders with high rate of disability,but sufficient attention has not been paid in this field.A large number of clinical studies have shown traditional Chinese acupuncture is a kind of effective treatment with less side effects.Through the analysis of literature regarding acupuncture and migraine published from 1981 to 2017 in CNKI and Pub Med databases,the mechanism of neural plasticity of acupuncture on chronic migraine was explored.It was believed the progress of chronic migraine involved the changes of neural plasticity in neural structure and function,and the neural plasticity related with neural sensitization during the process of chronic migraine was discussed from three aspects of electrophysiology,molecular chemistry and radiography.Acupuncture could treat and prevent chronic migraine via the mechanism of neural plasticity,but there was no related literature,hindering the further spreading and development of acupuncture for chronic migraine.