高压氧治疗重度颅脑外伤早期的疗效观察

The Effect of Early Hyperbaric Oxygen Therapy on Severe Craniocerebral Trauma

目的:观察早期高压氧治疗(HBO)对重度颅脑外伤治疗的效果。方法:将于2015年9月至2016年1月东莞市第三人民医院收治的重度颅脑外伤患者随机均分为对照组45例和观察组45例。观察组在发生颅脑外伤的8 d^1个月内进行HBO,对照组在发生颅脑外伤的1~2个月内进行HBO。比较分析两组患者治疗前及治疗后格拉斯哥昏迷指数(GCS)及日常生活能力(ADL)评分,在患者治疗出院后的6个月后对其临床效果进行评价。结果:经治疗,所有患者的GCS及ADL评分均明显优于治疗前,且比较差异具有统计学意义(P<0.05);观察组患者的GCS及ADL评分均明显优于对照组患者同期,且比较差异具有统计学意义(P<0.05)。治疗6个月后,观察组的格拉斯哥预后分级(GOS)结果明显高于对照组,差异具有统计学意义(P<0.05)。结论:对于病情稳定的重度颅脑外伤患者来说,尽早采用HBO能提高治疗效果和改善预后。

Objective To observe the effect of early hyperbaric oxygen therapy on severe craniocerebral trauma. Methods From September 2015 to January 2016, patients with severe traumatic brain injury were randomly divided into control group（45 cases） and experimental group（45 cases）. Hyperbaric oxygen therapy was performed in 8 days to 1 month after traumatic brain injury in the experimental group. Hyperbaric oxygen therapy was performed within 1 month to 2 months after craniocerebral trauma in the control group. The GCS and ADL scores of the two groups were compared before and after treatment. The clinical effect of the patients was evaluated after 6 months of treatment. Results After treatment, the GCS and ADL scores of all patients were significantly better than those before treatment, and the difference was statistically significant（P〈0.05）. The GCS and ADL scores of the experimental group were significantly better than those of the control group, The difference was statistically significant（P 0.05）. After 6 months of treatment, GOS grading of the experimental group was significantly higher than the control group, and the difference was statistically significant（P 0.05）. Conclusion For patients with severe craniocerebral trauma with stable disease, early use of hyperbaric oxygen therapy can improve the therapeutic effect and improve the prognosis.