肾病综合征高凝状态形成机制与中医治疗

Mechanism of hypercoagulability in nephrotic syndrome and traditional Chinese medicine treatment

由于内皮细胞的损伤、凝血系统的激活、抗凝血功能的低下、纤溶系统功能减弱、血小板功能亢进、糖皮质激素的使用等,使肾病综合征(NS)患者处于高凝状态,易发生血栓栓塞性疾病。中医认为其基本病机以脾肾亏虚为本,瘀血等证为标为实。中医的辨证论治、辨病与辨证结合等治疗,对其有良好临床疗效。

Patients with nephrotic syndrome（NS） are in a hypercoagulable state,and prone to suffering from thromboembolic diseases due to endothelial cell damage,coagulation system activation,anticoagulation dysfunction, weakened fibrinolytic system function, platelet hyperfunction, and the use of glucocorticoids. In traditional Chinese medicine（TCM） theory,the basic mechanisms of hypercoagulability in nephrotic syndrome includes spleen and kidney deficiency as the primary,and blood stasis and others as both the secondary and excess. The TCM treatment,based on syndrome differentiation and combination of disease differentiation and syndrome differentiation,may have good clinical efficacy for it.