冠心病患者动态动脉硬化指数与预后的相关性分析

Correlation Analysis Between Ambulatory Arterial Stiffness Index and Prognosis in Patients with Coronary Heart Disease

目的本研究通过观察冠心病患者的动态动脉硬化指数(ambulatory arterial stiffness index,AASI)与冠脉病变程度及危险评分之间的关系,从而判断动态动脉硬化指数在冠心病预后评估中的价值。方法选自2015年1月~2016年6月在笔者医院住院的187例冠心病患者为研究对象,根据AASI分组,比较组间一般情况、冠脉病变累计的血管支数,并对AASI与Gensini评分及GRACE评分进行相关性分析。结果一般特征:组间比较:性别、吸烟、血脂、尿素氮(BUN)、肌酐(Cr)、体重指数(BMI)等,差异无统计学意义;年龄、高血压及糖尿病的比例差异有统计学意义;组间冠脉病变累计的血管支数比较:3支病变及单支病变差异有统计学意义。AASI与Gensini评分之间呈正相关;AASI与GRACE评分之间呈正相关。结论 AASI不仅可用于对冠状动脉狭窄病变程度的判断,而且有助于冠心病预后的评价。

Objective To evaluate the AASI in the prognosis of patients with coronary heart disease by investigating the correlation between ambulatory arterial stiffness index and degree of coronary artery stenosis and risk score. Methods A total of 187 patients admit- ted to our hospital with diagnosis of coronary heart disease from Januaty 2015 to June 2016 were grouped by AASI. We compared the data in different groups about common character, coronary lesion count and investigate the correlation between ambulatory arterial stiffness in- dex and Gensini scores and GRACE score. Results The general clinical data： there were no significant differences in male patients,the proportion of smoking,blood lipids, urea nitrogen （BUN） , creatinine （Cr） , body mass index （BMI） between the two groups. Significant differences were observed in older patients and those with hypertension and diabetes. The number of disease dvessels,three vascular le- sions in the increased AASI group was more than normal AASI group. AASI was correlated with total Gensini scores positively. AASI was correlated with GRACE score positively. Conclusion AASI not only helps estimate the degree of coronary artery stenosis lesions, but al- so can be used to predict the prognosis of coronary heart disease.