86例单用阿立哌唑不良反应的临床分析

Clinical Analysis of 86 Cases of Adverse Drug Reactions Induced by Aripiprazole

目的探讨单用阿立哌唑所致不良反应(ADR)的规律与特点,以减少ADR事件的发生。方法分别在CNKI、维普、万方数据库检索2005~2016年关于阿立哌唑ADR个案报道的文献,汇总广州医科大学附属脑科医院在2005~2016年上报的阿立哌唑ADR事件,并对各项参数进行统计分析。结果汇总单用阿立哌唑ADR共86例,男性明显多于女性;对神经系统的损害(46.51%)最为常见,主要临床表现为锥体外系反应;ADR发生时有50%患者使用剂量为10~15 mg·d^(-1);血药谷浓度低于150 ng·mL^(-1),也可能发生严重ADR;进行血药浓度监测患者的严重ADR构成比较未进行血药浓度监测的小。结论临床上应重视阿立哌唑所致ADR,并加强用药监测。

OBJECTIVE To investigate and analyze the characteristics of adverse drug reactions（ ADR） induced by aripiprazole.METHODS Articles reported ADR induced by aripiprazole were searched in database system of Wanfang,VIP network and CNKI from 2005 to 2016,and ADR cases were collected from the Affiliated Brian Hospital of Guangzhou Medical University. RESULTS In86 ADR cases,the proportion of ADR in male patients was obviously higher than that in female patients. Nervous system damage was the most common ADR（ 46. 51%）,and the main performance was extrapyramidal system reaction. Among these cases,50% of patients received aripiprazole at a dose of 10-15 mg·d^-1. Serious ADR could happen even when the serum trough concentration was less than150 ng·mL^-1. The constituent ratio of severe adverse events in patients with serum concentration monitoring was less than that in patients without monitoring. CONCLUSION Great attention should be attached to ADR induced by aripiprazole in clinic,and strengthen the drug safety monitoring.