COX-2基因–765G>C位点多态性与结直肠癌易感性的meta分析

Correlation between –765G>C polymorphism of cyclooxygenase-2 gene and susceptibility to colorectal cancer: a meta-analysis

目的采用meta分析的方法定量评价环氧化酶-2(COX-2)基因–765G>C位点多态性与结直肠癌易感性的关系。方法计算机检索Pub Med、Embase、The Cochrane Library、CNKI、CBM、VIP和万方数据库,搜集有关COX-2基因–765G>C位点多态性与结直肠癌发病风险相关性的病例对照研究,检索时限均从建库至2016年5月。由两位评价员独立筛选文献并提取资料,采用Stata 12.0软件进行meta分析。结果共纳入13个病例对照研究,包括4 998例结直肠癌患者和7 750位健康对照者。总体人群的meta分析结果显示:COX-2基因–765G>C位点多态性与结直肠癌易感性无关[GG vs.GC:OR=0.98,95%CI(0.89,1.07),P=0.590;GC vs.CC:OR=0.85,95%CI(0.65,1.11),P=0.236;GG vs.CC:OR=0.86,95%CI(0.66,1.12),P=0.275;GG+GC vs.CC:OR=0.87,95%CI(0.67,1.13),P=0.288);GG vs.GC+CC:OR=0.97,95%CI(0.89,1.05),P=0.425]。亚组分析结果显示,COX-2基因–765G>C位点多态性的GG vs.GC和GG vs.GC+CC模型与亚洲人种结直肠癌的易感性可能有关[GG vs.GC:OR=0.70,95%CI(0.58,0.86),P=0.001;GG vs.GC+CC:OR=0.71,95%CI(0.58,0.87),P=0.001],而其他模型与结直肠癌的易感性无关[GC vs.CC:OR=1.74,95%CI(0.61,5.00),P=0.301;GG vs.CC:OR=1.18,95%CI(0.40,3.45),P=0.762;GG+GC vs.CC:OR=1.50,95%CI(0.53,4.23),P=0.440];COX-2基因–765G>C位点多态性与高加索人种结直肠癌的易感性无关[GG vs.GC:OR=1.05,95%CI(0.95,1.16),P=0.321;GC vs.CC:OR=0.80,95%CI(0.61,1.01),P=0.129;GG vs.CC:OR=0.85,95%CI(0.64,1.11),P=0.228;GG+GC vs.CC:OR=0.83,95%CI(0.64,1.09),P=0.198;GG vs.GC+CC:OR=1.03,95%CI(0.94,1.13),P=0.526]。结论当前证据显示,COX-2基因–765G>C位点多态性可能与亚洲人种结直肠癌易感性有关,而与高加索人种结直肠癌易感性无关。

Objective To evaluate correlation between -765G〉C polymorphism ofcyclooxygenase-2 （COX-2） gene and susceptibility to colorectal cancer. Methods The PubMed, Embase, The Cochrane Library, CNKI, CBM, VIP, and Wanfang databases were searched from inception to May 2016 to collect case-control studies about the -765G〉C polymorphism of COX-2 gene and the susceptibility to colorectal cancer. Two reviewers independently screened the literatures and extracted data of included studies. The meta-analysis was performed using Stata 12.0 software. Results A total of 13 studies involving 4 998 cases and 7 750 controls were included in this meta-analysis. The overall meta-analysis showed that all the genotypes of the -765G〉C polymorphism of COX-2 gene were not associated with the susceptibility to colorectal cancer [ GG vs. GC： OR=0.98, 95% CI （0.89, 1.07）, P=0.590; GC vs. CC：OR=0.85, 95% CI （0.65, 1.11）, P=0.236; GG vs. CC： OR=0.86, 95% CI （0.66, 1.12）, P=0.275; GG＋GC vs. CC： OR=0.87, 95% CI （0.67, 1.13）, P=0.288; GG vs. GC＋CC： 0R=0.97, 95% CI （0.89, 1.05）, P=0.425] . The stratification analysis by ethnicity showed that, the GG vs. GC and GG vs. GC＋CC modes of COX-2 gene -765G〉C polymorphism might be associated with the susceptibility to colorectal cancer in Asians [ GG vs. GC： OR=0.70, 95%CI （0.58, 0.86）, P=0.001; GG vs. GC＋CC： OR=0.71, 95% CI （0.58, 0.87）, P=0.001 ] , but the other modes were not associated with it [ GC vs. CC： OR=1.74, 95% CI （0.61, 5.00）, P=0.301; GG vs. CC： OR=1.18, 95% CI （0.40, 3.45）, P=0.762; GG＋GC vs. CC： OR=1.50, 95% CI （0.53, 4.23）, P=0.440 ] . The genotypes of the -765G〉C polymorphism of COX-2 gene were not associated with the susceptibility to colorectal cancer in Caucasians [ GG vs. GC： OR=1.05, 95% CI （0.95, 1.16）, P=0.321; GC vs. CC： OR=0.80, 95% CI （0.61, 1.01）, P=0.129; GG vs. CC： OR=0.85, 95% CI （0.64, 1.11）, P=0.228; GG＋GC vs. CC： OR=0.83, 95% CI （0.64, 1.09）, P=0.198; GG vs. GC＋CC： OR=1.03, 95% CI （0.94, 1.13）, P=0.526 ] . Conclusion Current evidence shows that -765G〉C polymorphism of COX-2 gene might be a genetic risk factor for colorectal cancer in Asians, but not in Caucasians.