成纤维激活蛋白的研究现状与展望

Current status and perspective in research of fibroblast activation protein

目的总结成纤维激活蛋白(fibroblast activation protein,FAP)的功能、作用机制以及其在靶向治疗方面的应用。方法复习近年来国内外有关FAP的相关研究文献并进行综述。结果 FAP与人二肽基肽酶Ⅳ具有重要的联系,具有丝氨酸蛋白酶活性,是肿瘤微环境中重要的免疫抑制成分。FAP参与肿瘤性和非肿瘤性疾病的病理过程。在靶向治疗中,针对FAP的酶活性抑制物、抗体、疫苗及前体药物被广泛研究。结论 FAP功能多样,参与多种疾病的病理过程,同时对肿瘤靶向治疗的研究具有重要意义。

Objective To summarize functions and mechanisms of fibroblast activation protein （FAP） and its application in targeted therapy. Method Literatures about FAP in recent years were collected to make a review. Results There is an important relationship between the FAP and the dipeptidyl peptidase-IV. FAP has a serine protease activity and is an important immunosuppressive component in the tumor microenvironment. FAP participate in the pathological process of the neoplastic and the non-neoplastic diseases. In the targeted therapy, the enzyme inhibitors, antibodies, vaccines, and prodrugs of FAP had been extensively studied. Condusion FAP have various functions and participates in pathological process of many diseases, and it is of great significance to research of tumor targeted therapy.