新疆地区Kaposi肉瘤59例临床分析

Clinical Features and Prognosis of Kaposi's sarcoma:A Retrospective Study in 59 Patients in Xinjiang Uighur Autonomous Region

目的了解新疆地区Kaposi肉瘤(Kaposi's sarcoma,KS)患者的临床特征,探讨最佳治疗方案及其转归的影响因素。方法回顾性分析本院2002年3月-2016年6月诊治的59例KS患者临床资料。结果59例KS患者中,36例经典型KS,22例艾滋病相关型卡波西肉瘤(AIDS-KS),1例医源性KS。以维吾尔族男性为主,与AIDS-KS患者相比,经典型KS患者发病年龄及病程更长,皮损多局限于四肢远端,少见于头面部、躯干及口腔黏膜,少有浅表淋巴结肿大及内脏器官受累。经典型KS患者以放疗及系统免疫治疗为主,AIDS-KS应积极进行高效抗反转录病毒治疗(HAART),必要时可行联合放疗,疗效较好。结论新疆地区经典型KS与AIDS-KS患者临床特征及治疗转归明显不同,KS多见于维吾尔族,经典型KS皮损以四肢远端受累为主,很少累及内脏器官,病变呈相对良性的过程,大多数患者对局部放疗或系统药物治疗有效。AIDS-KS皮损广泛,易累及内脏器官,预后较经典型KS差。

Objective To analyze the clinical features of KS patients in Xinjiang Uighur Autonomous Region,and to discuss the therapy and prognosis of KS.Methods Collected clinical data from 59 KS patients that were retrospectively analyzed in department of dermatology and infectious diseases of the First Teaching Hospital of Xinjiang Medical University from March 2002 to June 2016.Results Xinjiang is located in the main area of classic KS.Among the 59 patients with KS,36 were classic KS,22 were AIDS-KS and 1 was iatrogenic KS.KS patients were mainly among Uygur males.Compared with AIDS-KS patients,the onset age and duration of classic KS patients were longer.The lesions were mostly confined to the distal extremities,and they located rarely in the head and face. Trunk and oral mucosa. What is inore there were few superficial lymph node enlargement and organ involvement.Classic KS patients mainly treated with radiotherapy and systemic immunotherapy,while AIDS-KS patients should actively carry out the highly active antiroviral therapy（HAART）,when necessary,the combination of radiotherapy could achieve good curative effect.Conclusion The clinical characteristics and the outcomes of classic KS and AIDS-KS patients were significantly different from each other in Xinjiang uygur autonomous region. Classic KS was mainly occurred in uygur and KS lesions were involved on the distal extremities,rarely involved visceral organs; Classic KS was a relatively benign process,and most of the patients were effective with local radiation therapy or systemic drug therapy.AIDS-KS lesions were extensive and easily involved the visceral organs,the prognosis is worse than classic KS.