艾滋病并发复数菌败血症患者12例临床分析

Clinical Analysis of Plural Pathogenic Septicemia in 12 Patients with AIDS

目的观察艾滋病并发复数菌败血症患者临床特征和药物敏感试验结果。方法回顾性分析本院12例艾滋病并发复数菌败血症患者的合并症、炎症指标、预后情况、病原菌分布及药敏结果。结果 12例艾滋病患者有10种合并症,检测血清降钙素原(4.75±9.43)μg/L,仅5例升高,院内感染7例,死亡3例;共检出24株菌株,革兰阴性菌8株(33.3%),多重耐药的大肠埃希菌和肺炎克雷伯菌共6株,产超广谱β-内酰胺酶5株;革兰阳性菌13株(54.2%)以溶血性葡萄球菌和金黄色葡萄球菌多见。结论艾滋病合并复数菌败血症患者合并症多样,病死率高,革兰阴性菌耐药比重大,应积极预防及处理。

Objective To study the clinical features and distribution characteristics and drug sensitivity of plural pathogenic septicemia in AIDS patients.Methods Data of 12 AIDS with plural pathogenic septicemia concerning complications,inflammatory markers,prognosis,distribution of pathogens and drug sensitivity were analyzed retrospectively.Results There were 10 kinds of comorbidity in 12 AIDS patients,including nosocomial infection in 7 cases,3 patients died.The plasma levels of procalcitonin were（4.75±9.43）μg/L and elevated only in 5 cases; 24 strains were detected of which 8 strains were Gram-negative bacteria（ 33.3%）,and 6 strains of Escherichia coli and Klebsiella pneumoniae were multidrug-resistance strains and producing 5 strains of ESBLs.Staphylococcus hominis and Staphylococcus aureus were the main pathogens of 13 Gram-positive bacteria（ 54.2%）.Conclusions AIDS with plural pathogenic septicemia had multiple complications,high mortality and resistance in G-bacill.It is nuessary to prevent and treat actively.