原发性高血压病人超敏C反应蛋白与血压及血管内皮功能关系的研究

Effect of high-sensitive C-reactive protein on vascular endothelial function in patients with essential hypertension

目的探讨原发性高血压病人血压、血管内皮功能与超敏C反应蛋白(high-sensitive C-reactive protein,hs-CRP)的关系。方法入选111例未经治疗的轻度原发性高血压病病人,并根据hs-CRP的数值将高血压病人分为2组:高hs-CRP组(hs-CRP>2.78)42例和低hs-CRP组(hs-CRP≤2.78)69例。所有受试者均行Endo-PAT2000无创内皮功能检测仪检测反应性充血指数(reactive hyperemia index,RHI),并检测hs-CRP,测量收缩压及舒张压。结果高hs-CRP组收缩压及脉压明显高于低hs-CRP组;Pearson相关分析结果表明,hs-CRP与收缩压(r=-0.247,P=0.010)呈负相关。结论炎性反应因子可能与原发性高血压病人血管内皮损伤有关,但仍需要进一步纵向研究来更好的阐明内皮功能与炎性反应因子之间的因果关系。

Objective To investigate the relationship between inflammation factor and endothelial function in essential hypertensive patients. Methods We continuedly enrolled 111 hypertensives from the Xuanwu Hospital Capital Medical University under the strict inclusion criteria. The Endo-PAT2000（Itamar Medical Inc.Caesarea） noninvasive testing equipment of vascular endothelial function measured reactive hyperemia index （RHI） which evaluate vascular endothelial function and arterial stiffness were operated in morning fasting adoption.Patients are divided into two groups：high high-sensitivity C-reactive protein（hs-CRP） group （hs-CRP〉2.78,n=42）,low hs-CRP group （hs-CRP ≤ 2.78,n=69）. We also recorded age, blood pressure, history of smoking, fasting blood check hs-CRP. Results Systolic blood pressure and pulse pressure in high hs-CRP group were significantly higher than in low hs-CRP group.The pearson correlation analysis indicated that, RHI is negatively associated with hs-CRP（r=-0.247, P=0.010）.Conclusion RHI gradually declined with the elevation of inflammation factor levels in hypertensives, and there is a linear correlation between them, which hinted that they may be associated with hypertensives endothelial injury. Further longitudinal studies are needed to better understand the causal relationship between endothelial function and inflammatory cytokines.