丁苯酞软胶囊治疗急性脑梗死的临床效果及对炎症介质的影响

Clinical efficacy of butylphthalide soft capsule in the treatment of acute cerebral infarction and its effect on inflammatory mediators

目的观察丁苯酞软胶囊治疗急性脑梗死的临床效果及对炎症介质的影响。方法 93例急性脑梗死患者分为A组(即丁苯酞软胶囊组,48例)和B组(即对照组,45例)。B组采用常规治疗,A组在常规治疗的基础上口服丁苯酞软胶囊。评价两组的日常生活能力和神经功能缺损程度。检测两组的炎症指标(TNF-α、IL-6和超敏C反应蛋白)。结果A组的总有效率高于B组(P<0.01);出院时的用Barthel指数高于B组(P<0.01),NIHSS值低于B组(P<0.01);TNF-α、IL-6和超敏C反应蛋白水平均明显低于B组(P<0.01)。结论丁苯酞软胶囊治疗急性脑梗死可减轻神经功能缺损,提高日常生活能力和总有效率,值得推荐。

Objective To observe the clinical efficacy of butylphthalide soft capsule in the treatment of acute cerebral infarction and its effect on inflammatory mediators. Methods 93 cases with acute cerebral infarction were divided into butylphthalide soft capsules group （48 cases, Group A） and control group （45 cases, Group B）. Group B received routine treatment while Group A additionally received oral administration with butylphthalide soft capsules. The ability of daily living and the degree of neurological deficit of the two groups was evaluated with barthel index （BI） and national institutes of health stroke scale （NIHSS）. The inflammation indices （TNF-α, IL-6 and high sensitive C reactive protein） were detected in the two groups. The data of two groups were compared using t test, rank test or Chi square analysis. Results The total effective rate of Group A was significantly higher than that of Group B （P〈0.05）. The BI value of Group A at discharge was significantly higher than that in Group B （P〈0.05）. The NIHSS value of Group A at discharge was significantly lower than that in Group B （P〈0.05）. After treatment, the inflammation indices （TNF-α, IL-6 and high sensitive C reactive protein） in Group A were significantly lower than those in Group B （P〈0.05）. Conclusion Butylphthalide soft capsules can reduce the neurological deficit and improve the ability of daily living and the total effective rate in treatment of acute cerebral infarction, so it is worth clinical promotion.