降钙素原对慢性阻塞性肺疾病急性加重期使用抗菌药物的参考价值

Reference value of procalcitonin on antibacterial usage in acute exacerbation of chronic obstructive pulmonary disease

目的探讨降钙素原(PCT)在慢性阻塞性肺疾病急性加重期(AECOPD)选用抗菌药物中的参考价值。方法将92例AECOPD患者随机分为观察组和对照组,观察组依据PCT质量浓度决定是否使用抗菌药物,对照组则根据临床表现及抗生素治疗指南使用抗菌药物。比较两组疗效、抗菌药物构成比及使用时间、住院时间及费用等。结果两组近期、远期疗效差异均无统计学意义(P>0.05);观察组抗菌药物构成比及使用时间、住院时间及费用均明显少于对照组(P<0.05)。结论 PCT指导使用抗菌药物可降低AECOPD患者抗菌药物使用率及疗程、减少住院时间和费用。

Objective To investigate the reference value of procalcitonin （PCT） on antibacterial usage in acute exacerbation of chronic obstructive pulmonary disease （AECOPD）. Methods Ninety-two patients with AECOPD were randomized to observation and control groups. The antibacterial usage was dependent upon PCT concentration in observation group and clinical manifestations and antibiotic therapy guidelines in control group. Curative effect, constituent ratio and usage time of antimicrobial agents, and hospital stay and expense were compared between two groups. Results The short- and long-term efficacy was comparable between two groups （P〉0.05）. The constituent ratio and usage time of antibacterial agents, and hospital stay and expense were lower in observation group than in control group （P〈0.05）. Conclusion PCT- guided antibacterial application can reduce the antibiotic usage and course as well as hospital stay and expense in patients with AECOPD.