胃癌患者术前血清胸苷激酶-1水平与TNM分期、复发以及生存期的关系

Relationship between preoperative serum thymidine kinase-1 in the patients with gastric cancer and TNM staging,recurrence and lifetime

目的探讨胃癌患者术前血清胸苷激酶1(STK1)水平与胃癌分期、复发以及患者生存期的关系。方法选择171例胃癌患者(其中Ⅰ期36例、Ⅱ期32例、Ⅲ期47例、Ⅳ期56例),采用化学发光免疫分析技术测定其STK1的含量,分析STK1水平与胃癌分期、复发及生存期的关系。结果不同TNM分期胃癌患者的STK1表达水平差异有统计学意义,TNM分期越高的患者其STK1水平越高(P<0.01)。STK1表达量高的患者易复发(P<0.05),生存期随STK1水平的升高而缩短(P<0.01)。结论胃癌患者术前STK1水平对肿瘤的病情判断和预后评估有一定的参考价值。

objective To investigate the relationship between preoperative serum thymidine kinase -1 （STK1） in the patients with gastric cancer and TNM staging, recurrence and lifetime. Methods The serum samples of 171 cases of gastric cancer patients （of which there were 36 cases in Stage I, 32 cases in Stage II, 47 cases in Stage III and 56 cases in Stage IV） were collected. Chemiluminescence immunoassay was used to detect the content of STK1, and the relationship between STK1 level and TNM staging, recurrence and lifetime. Results The patients of different TNM staging showed statistical difference in the STK1 level, the higher stage the patients, the higher level the STK1 level （P〈0.01）. The patients with a higher STK1 level were prone to have recurrence （P〈0.05）; their lifetime was shortened with the increase of STK1 level （P〈0.0I）. Conclusion The preoperative serum STK1 level of gastric cancer patients has certain clinical value for the diagnosis and prognosis evaluation of tumors.