扩张型心肌病与缺血性心肌病患者的血糖、血脂水平比较及其与心功能的关系

The comparison of blood glucose and serum lipid level between the patients with dilated cardiomyopathy and ischemic cardiomyopathy and its relationship with cardiac function

目的探讨扩张型心肌病与缺血性心肌病患者血糖、血脂水平的差异,并分析其与心功能的相关性。方法收集2007年1月1日-2014年12月31日期间收治的扩张型心肌病和缺血性心肌病患者的血脂及血糖水平数据,分析两者之间的差异,并分析其与心功能的相关性。结果缺血性心肌病患者的血清总胆固醇、甘油三酯和低密度脂蛋白水平均显著高于扩张型心肌病患者(P<0.01)。扩张型心肌病、缺血性心肌病患者的血糖以及高密度脂蛋白水平差异无统计学意义(P>0.05)。高密度脂蛋白水平与扩张型心肌病患者及缺血性心肌病患者的心功能均呈负相关(r=-0.39、0.45,P<0.05);总胆固醇、甘油三酯与缺血性心肌病患者的心功能呈正相关(r=0.41、0.43,P<0.05),与扩张型心肌病患者的心功能无明显相关性(r=0.21、0.11,P>0.05)。结论扩张型心肌病患者与缺血性心肌病患者的血脂水平存在一定差异;血脂水平异常与缺血性心肌病患者心功能的关系更为密切。

Objective To investigate the difference in blood glucose and lipid level of the patients with dilated cardiomyopathy and ischemic cardiomyopathy, and analyze its relationship with cardiac function. Methods The data of blood lipid and blood glucose level of the patients with dilated cardiomyopathy and ischemic cardiomyopathy admitted and treated from December 31, 2012 to January 1, 2005 were collected. The difference between the patients and its relationship with cardiac function was analyzed. Results The serum total cholesterol, triglyceride and low density lipoprotein levels in the patients with dilated cardiomyopathy were significantly lower than those of the patients with ischemic cardiomyopathy, and the difference was statistically significant （P〈0.01）. There was no statistical difference in blood glucose level and high density lipoprotein level between the patients with dilated cardiomyopathy and ischemic cardiomyopathy （P〉0.05）. The high density lipoprotein level was negatively correlated to the cardiac function of the patients with dilated cardiomyopathy （r=-0.39, p=0.047） and ischemic cardiomyopathy （r=-0.45, P〈0.05）. The total cholesterol （rs=0.41, p=0.035） and triglyceride （r=0.43, P〈0.05） were positively correlated to the cardiac function of the patients with ischemic cardiomyopathy, but had no significant correlation to the cardiac function of the patients with dilated cardiomyopathy （r=0.21, 0.11, P〉0.05）. Conclusion There are some differences in serum lipid levels of the patients with dilated cardiomyopathy and ischemic cardiomyopathy. The abnormal blood lipid level is more closely correlated to the cardiac function of the patients with ischemic cardiomyopathy.