老年不稳定型股骨粗隆间骨折患者股骨近端内固定术后联合应用唑来膦酸和降钙素的效果观察

Postoperation application of zoledronic acid and calcitonin in elderly patients with unstable intertrochanteric fracture undergoing proximal femoral nail antirotation

目的观察老年不稳定型股骨粗隆间骨折患者股骨近端内固定(PFNA)术后联合应用唑来膦酸和降钙素的效果。方法 106例老年不稳定型股骨粗隆间骨折患者行PFNA术,术后分别给予唑来膦酸联合降钙素(研究组)、降钙素(对照组)治疗。比较健侧髋部骨密度、SF-12健康调查量表评分、Harris髋关节功能评分、视觉模拟评分及不良事件。结果研究组健侧髋部骨密度、SF-12躯体及心理评分、髋关节功能均明显高于对照组(P<0.01或0.05),而再骨折发生率低于对照组(P<0.05)。结论老年不稳定型股骨粗隆间骨折患者PFNA术后联合应用唑来膦酸和降钙素可改善髋关节功能和生活质量。

Objective To observe the postoperation effect of zoledronic acid and calcitonin on elderly patients with unstable intertrochanteric fracture （ICF） undergoing proximal femoral nail antirotation （PFNA）. Methods A total of 106 elderly patients with unstable ICF were treated with PFNA, and then received zoledronic acid plus calcitonin （study group） or calcitonin therapy （control group）. Hip bone mineral density of the unaffected side, SF-12 Health Survey Scale, Harris Hip Score, visual analog scale, and adverse events were compared between two groups. Results Compared with control group, hip bone mineral density of the unaffected side, physical and mental scores of SF-12, hip scores were increased （P〈0.01 or 0.05）, but incidence of refracture was decreased in study group （P〈0.05）. Conclusion The combined application of zoledronic acid and calcitonin can improve the hip joint function and quality of life in elderly patients with unstable ICF undergoing PFNA.