银杏内酯注射液联合阿司匹林治疗缺血性脑卒中的临床观察

Clinical observation of ginkgolide injection and aspirin in ischemic stroke

目的观察银杏内酯注射液联合阿司匹林对大动脉粥样硬化性缺血性脑卒中的治疗效果。方法 96例大动脉粥样硬化性缺血性脑卒中患者随机分为对照组和研究组,对照组口服阿司匹林200 mg/d,研究组在此基础上注射银杏内酯注射液10 mL/d,连续用药14 d;比较两组的疗效、美国NIH卒中量表(NIHSS)、日常生活能力(ADL)量表评分以及血浆血小板活化因子(PAF)水平。结果研究组有效率、ADL评分明显高于对照组,而NIHSS评分和血浆PAF水平明显低于对照组(P<0.01或0.05)。结论银杏内酯注射液可改善大动脉粥样硬化性缺血性脑卒中患者的脑神经功能和生活自理能力。

Objective To observe the therapeutic efficacy of ginkgolide injection and aspirin in large artery athero- sclerotic ischemic stroke （LAAIS）. Methods Ninety-six patients with LAAIS were randomized to study and control groups, and respectively treated with oral aspirin （200 mg/d） and addition of ginkgolide injection for 14 days. The therapeutic efficacy, NIH Stroke Scale （NIHSS） and Activity of Daily Living （ADL） scale and plasma platelet activating factor （PAF） levels were compared between two groups. Results Compared with control group, therapeutic efficacy and ADL scores were increased, while NIHSS scores and plasma PAF levels decreased in study group （P〈0.01 or 0.05）. Conclusion Ginkgolide injection can improve the neurological function and self-care ability of patients with LAAIS.