联合检测血清CA125、CA199在消化系统恶性肿瘤诊断中的价值

The diagnostic value of combination serum levels of CA125 and CA199 in digestive system cancer

目的:探讨单独或联合检测血清CA125,CA199在消化系统恶性肿瘤诊断中的价值。方法:收集2012年1月至2014年12月在我院住院患者,消化系统恶性肿瘤患者60例为恶性肿瘤组,所有患者均通过内镜或者病理明确诊断。应用放射免疫法测定患者血清CA125、CA199表达水平,并分析CA125、CA199单独诊断及联合诊断的效能分析。结果:检测肿瘤标记物CA125、CA199的高表达均提示存在消化系统恶性肿瘤的可能,而检验效能不一。消化系统恶性肿瘤组患者血清标志物CA125、CA199水平、阳性比例及水平均高于对照组(P<0.05)。CA199敏感度最高为46.67%,特异性为87.50%,CA125的特异性最高为90%,敏感性为41.67%,CA125与CA199联合时敏感度、特异度分别提高至96.25%,48.33%,AUC_(ROC)为0.769,均高于各指标单一检测时的结果(P<0.05)。结论:联合检测血清CA125、CA199能够提高消化系统恶性肿瘤的诊断效能。

Objective：To assess the clinical value of single or combination serum CA125 ,CA199 in the diagnosis of digestive system cancer. Methods ：60 patients with digestive system cancer were enrolled in the hospital from Janu- ary 2012 to December 2014. CA125, CA199 expression levels were measured by radioimmunoassay before treatment. The sensitivity, specificity and the areas under the receiver operating characteristic curve of these two tumor markers were analyzed for diagnosis of digestive system cancer. Results：Detection the expression of tumor marker CA125, CA199 indicated the presence of the possibility of malignancy in the digestive system, the diagnostic performance of digestive system cancer were different. The serum levels and positive rate of CA125 and CA199 in the digestive system malignant tumor group were higher than the control group （P 〈 0.05 ）. The sensitivity of CA199 was 46.67%, but the specificity was only 87.50%. On the other hand, the specificity of CA125 was 90% , but the sensitivity was 41.67%. When combined with CA125 and CA199, the sensitivity, specificity were 96.25% ,48.33%, respectively, and AUCRoc was 0. 769, all the results were higher than single one （P 〈 0.05）. Conclusion：The combined detection of serum CA125, CA199 can improve the diagnostic performance of digestive system cancer.