新生儿心肌损伤标志物检测

Analysis of markers of myocardial injury in neonates with common clinical diseases

目的探讨常见新生儿疾病患者肌酸激酶同工酶(CK-MB)、高敏心肌肌钙蛋白T(hs-CTn T)及肌红蛋白(Mb)水平变化及检测的临床意义。方法测定129例高胆红素血症新生儿,118例早产儿,47例缺氧性疾病新生儿,152例肺炎新生儿及49例健康新生儿的CK-MB、hs-CTn T和Mb水平,并进行比较。结果四种疾病组患儿的CK-MB和Mb水平均明显高于健康新生儿对照组(P<0.05)。但除高胆红素血症外,其他三组的hs-CTn T水平与健康新生儿差异无统计学意义(P>0.05)。此外,将缺氧性疾病患儿与其他三种病症患儿作比较,CK-MB和Mb水平的差异有统计学意义(P<0.05)。高胆红素血症新生儿三项心肌标志物水平与总胆红素(TBil)水平的相关性差异均无统计学意义(P>0.05)。结论应联合检测三种心肌标记物用于患儿心肌受损情况诊断,为临床早期诊疗提供参考。

Objective To investigate the clinical value of detection of creatine kinase-MB（CK-MB）,high sensitive-cardiac troponin T（hs-CTn T）and myoglobin（Mb）in neonates with common diseases. Methods The levels of CK-MB,hs-CTn T and Mb were determined and compared between 129 cases of neonatal hyperbilirubinemia,118 cases of preterm children,47 cases of neonatal hypoxic children,152 cases of children with neonatal pneumonia and 49 healthy newborns. Results The levels of CK-MB and Mb in the four groups were significantly higher than those in the control group（P〈0.05）.However,except for hyperbilirubinemia,the hs-CTn T level of other three groups and that of the healthy newborns was no statistically significant difference（P〉0.05）. In addition,children with hypoxic disease compared with the other three kinds of children with disease,CK-MB and Mb levels were statistically significant different（P〈0.05）. There was no significant correlation between the levels of three markers of myocardium and total bilirubin（TBil）in hyperbilirubinemia neonates（P〈0.05）. Conclusions The three kinds of myocardial markers should be used in diagnosis of myocardial damage in children with four kinds of diseases,and provide experimental basis for early clinical diagnosis and treatment.