乌拉地尔和尼卡地平治疗急症高血压临床疗效比较

Comparison of Clinical Efficacy of Urapidil and Nicardipine in the Treatment of Acute Hypertension

目的探讨乌拉地尔和尼卡地平各自治疗急症高血压临床疗效。方法选取我院急诊科收治的高血压急症患者为研究对象,根据治疗方案的不同分为A组和B组。A组患者给予乌拉地尔治疗,B组患者给予尼卡地平治疗,比较两组患者的降压效果和心功能水平。结果两组治疗60min后血压值均达到有效目标值,其中A组患者治疗后5min血压水平与治疗前比较明显下降(P<0.05);B组患者治疗后30min血压水平与治疗前比较明显下降(P<0.05);A组治疗后30min、治疗后60min心率明显低于治疗前(P<0.05);B组治疗后30min、治疗后60min心率明显高于治疗前(P<0.05);与治疗前比较,两组患者经治疗后LVEDD、LAD以及LVEF水平均有明显改善(P<0.05)。结论乌拉地尔和尼卡地平具有显著的降压效果,但是乌拉地尔起效更快,且可在一定程度上降低心率,适用范围更广,更适合高血压急症的治疗。

Objective To investigate the clinical efficacy of Urapidil and nicardipine in the treatment of acute hypertension.Methods Selected patients with hypertensive emergencies in our hospital emergency department for the study,according to different treatment options, divided into group A and group B. The patients in group A were treated with urapidil, and the patients in group B were treated with nicardipine.The antihypertensive effect and cardiac function were compared between the two groups.Results The blood pressure reached the effective target value of two groups after the treatment of 60 min, the treatment of A patients with 5min after blood pressure level compared with before treatment significantly decreased（P〈0.05）;B group patients after treatment of 30 min level and blood pressure decreased significantly（P〈0.05）;A group 30 min after treatment, after treatment of 60 min the heart rate was significantly lower than that before treatment（P〈0.05）; B group after treatment, 30 min, 60 min after treatment of heart rate was significantly higher than before treatment（P〈0.05）;Compared with before treatment, two groups of patients after treatment, LVEDD, LAD and LVEF levels were significantly improved（P〈0.05）.Conclusion Urapidil and nicardipine have significant antihypertensive effect, but urapidil has a quicker onset and can reduce heart rate to a certain extent. It is suitable for the treatment of hypertensive emergencies.