摘要
由于异噁唑衍生物具有广泛的除草、杀虫和药物活性,其合成方法近年来一直引起关注.以3-芳基-5-溴甲基异噁唑为原料,经溴代、醚化、Suzuki偶联反应合成了一系列3,4-二取代芳基-5-芳氧甲基异噁唑化合物,初步的生物活性测试结果显示,部分化合物对粘虫显示出一定的杀虫活性.
Due to isoxazole derivatives possess a wide range of herbicidal, insecticidal and pharmacological activitives, the synthetic methodologies for preparation of isoxazole derivatives have drawn much attention in recent years. Herein, 3,4-diaryl-5-aryloxymethyl isoxazole derivatives were effectively synthesized from 3-aryl-5-(bromomethyl)isoxazole via consecutive bromination, etherification, followed by Suzuki coupling reaction catalyzed by Pd(PPh3)2Cl2. Preliminary bioassay data showed that some of the title compounds exhibited certain insecticidal activities against Oriental armyworm.
作者
蒋海芳
张敏
张丽
陈雅丽
朱宁
宋力平
邓红梅
Jiang Haifang Zhang Min Zhang Li Chen Yali Zhu Ning Song Liping Deng Hongmei(Department of Chemistry, School of Science, Shanghai University, Shanghai 200444 Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032 Laboratory for Microstructures, Shanghai University, Shanghai 200444)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2017年第9期2399-2408,共10页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.21272153)资助项目~~
关键词
异噁唑衍生物
溴代
醚化
SUZUKI偶联反应
isoxazole derivatives
bromination
etherifieation
suzuki coupling reaction