基因多态性影响房颤射频消融术后复发的研究进展

Effects of Gene Polymorphisms on Recurrence of Atrial Fibrillation after radiofrequency Ablation

心房颤动(房颤)是临床上常见的心律失常,可引起心力衰竭、增加卒中风险以及心血管疾病的病死率,其发病率与死亡率逐年增加,急需有效的治疗方法。近年来,射频消融已逐步发展成为治疗房颤的最有效方法之一,具有安全性高、治疗效果好等优点。然而,经射频消融治疗后的房颤复发率较高,可达20%~60%。因此研究影响房颤患者经射频消融治疗后复发因素十分迫切。除了传统的影响因素(如性别、年龄、高血压、体重指数等)外,多项研究发现多种基因多态性与房颤射频消融术后复发有关。本文对近几年基因多态性对房颤射频消融术后复发的影响以及相关机制进行了综述。

Atrial fibrillation （AF）, with increasing morbidity and mortality, is the most common clinical arrhythmia, which can cause heart failure and increase the risk of stroke and the mortality of cardiovascular disease. Therefore, there is an urgent need for effective therapy. In recent years,radiofrequency ablation has been gradually developed into one of the most powerful techniques for treating AF with high safety and excellent therapeutic effect. However, the recurrence rate of AF after radiofrequency ablation is still high （up to 20%-60%）. Therefore, it is important to investigate the risk factors for the recurrence of AF after radiofrequency ablation. Besides the traditional factors, such as gender, age, hypertension and body mass index, many studies have reported that gene polymorphisms were associated with the recurrence of AF after radiofrequency ablation. In this article, the effect of gene polymorphisms on the recurrence of AF after radiofrequency ablation and its related mechanisms were reviewed.