粒-巨噬细胞集落刺激因子漱口液治疗异基因造血干细胞移植相关的口腔黏膜炎的效果评价

Effect of granulocyte-macrophage colony-stimulating factor gargle in control of the oral mucositis after allogeneic hematopoietic stem cell transplantation

目的 探讨粒-巨噬细胞集落刺激因子（GM-CSF）漱口液对异基因造血干细胞移植（allo-HSCT）患者口腔黏膜炎（OM）的治疗效果.方法 选取2014年1月至2015年1月接受异基因造血干细胞移植的134例患者为研究对象,将其按照随机数字表法分成试验组65例和对照组69例,2组患者均接受日常OM的预防措施.当发生OM后,对照组患者继续接受原常规护理方法,试验组患者在原有护理措施基础上加用GM-CSF漱口液.比较2组患者OM的治疗有效率和愈合时间.结果 试验组患者OM的治疗有效率为81.54%（53/65）,对照组为24.64%（17/69）,2组比较差异有统计学意义（χ2=43.434,P=0.000）;试验组的中位愈合时间为4.5 d,对照组的中位愈合时间为9.0 d,2组比较差异有统计学意义（Z=-5.379,P=0.000）.结论 GM-CSF漱口液对allo-HSCT患者OM有显著的治疗效果,可以明显促进口腔溃疡的愈合.

Objective To identify the efficacy of granulocyte-macrophage colony-stimulating factor （GM-CSF） gargle in patients who had oral mucositis after allogeneic hematopoietic stem cell transplantation. Methods A total of 134 patients were enrolled in this study from 2014 to 2015. They were randomly divided into two groups：the experimental group （n=65） and the control group （n=69）. Both groups received preventive measures for oral mucositis. But once oral mucositis occurred, the control group continued with the routine nursing measure, while the experimental group added GM-CSF gargle based on previous routine nursing measure. The effective rate and healing time were compared between two groups. Results The effective rate of the experimental group （81.54%, 53/65） was significantly higher than that of the control group （24.64%,17/69） （χ2=43.434, P=0.000）. The median healing time in the experimental group was 4.5 days, shorter than 9.0 days in the control group （Z=-5.379, P〈 0.01）. Conclusions GM-CSF gargle can control the oral mucositis after allogeneic hematopoietic stem cell transplantation.