药物性肝损伤335例临床分析

Clinical analysis of 335 cases of drug-induced liver injury

[背景]探讨药物性肝损伤(DILI)的致病药物、临床特征及预后.[病例报告]选择2009年1月—2016年12月间在延边大学附属医院接受住院治疗的335例DILI患者的临床资料进行回顾性分析.DILI的发病率呈上升趋势,男女比例为1∶1.77.引起DILI的最常见药物是中药,占48.36%(162例),发生肝损伤的时间以服药后2周内居多,占39.70%(133例);临床表现无特异性,肝损伤程度以3级(重度)为主,占51.64%(173例);治疗有效率为91.64%.[讨论]中药是引起DILI的主要病因,加强中药使用中肝功能的监测较重要,多数DILI患者预后较好.

BACKGROUND To investigate the causative drugs,clinical characteristics and prognosis of drug-induced liver injury（DILI）.CASE REPORTS Clinical data of 335 patients with DILI who accepted hospitalization in Yanbian university hospital from January 2009 to December 2016 were selected and retrospectively analyzed.The morbidity of DILI tended to increase and the ratio of male to female was 1∶1.77.The most common drug that induced liver injury was traditional Chinese herbs（TCH）,accounting for 48.36%（162 cases）.Liver injury occurred more often within 2 weeks after taking the drug,accounting for 39.70%（133 cases）.The clinical manifestation was nonspecific.The severity of liver injury was predominated by degree 3,accounting for 51.64%（173 cases）,and the effective rate of the treatment was 91.64%.DISCUSSION TCH was the main cause of DILI.It was very important to strengthen the liver function monitoring during the use of TCH.The prognosis of majority of patients with DILI was good.