脑梗死后抑郁状态血浆同型半胱氨酸水平及相关因素分析

Analysis of plasma homocysteine level and related factors in patients with depression after cerebral infarction

目的研究血浆同型半胱氨酸与脑梗死后抑郁的相关性。方法对经头颅CT和(或)MRI确诊的170例脑梗死患者进行汉米尔顿抑郁量表评分,分为脑梗死后抑郁组和对照组,同时所有患者检测同型半胱氨酸,分析同型半胱氨酸与脑梗死后抑郁的相关性。结果脑梗死后抑郁组同型半胱氨酸水平(24.86±7.21)μmol/L明显高于对照组(12.62±3.40)μmol/L,差异有统计学意义(P<0.05)。将脑梗死后抑郁患者进行轻、中、重分组比较,差异有统计学意义(P<0.05)。结论脑梗死后抑郁与同型半胱氨酸水平相关,其严重程度与同型半胱氨酸水平相关。

Objective To research the relationship between plasma homocysteine and depression after cerebral infarction.Methods 170 patients with cerebral infarction diagnosed by the head CT/MRI were estimated by Hamilton Depression Scale score and divided into depression after cerebral infarction group and control group.At the same time,all patients were tested for homocysteine,the relationship between homocysteine level and depression after cerebral infarction was analyzed.Results The level of homocysteine（24.86±7.21μmol/L）in the depression after cerebral infarction group was significantly higher than that in the control group（12.62±3.40μmol/L）,and the difference was statistically significant（P〈0.05）.The patients with depression after cerebral infarction were divided into mild,moderate and severe groups.The difference was statistically significant（P〈0.05）.Conclusion The depression after cerebral infarction is correlated with homocysteine and its severity is correlated with the level of homocysteine.